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Anabolic hormones (ASs) have a strong protein assimilation effect, mainly by enhancing assimilation metabolism, inhibiting alienation or oxidative metabolism, which can increase protein deposition and reduce fat ratio, thereby increasing feed conversion rate and achieving a significant increase in the economic benefits of animal breeding Purpose
.
Anabolic hormones have been used in animal husbandry for 50 years, and anabolic hormones are one of the most important drugs with residual toxicological significance
Non-steroidal anabolic hormones are mainly non-steroidal female sex hormones, which refer to a class of substances that have a different chemical structure from steroidal estrogen but also have estrogenic effects, mainly including stilbenes and lesonic acid lactone Or dihydroxybenzoic acid esters (resorcylic acid lactones, RALs) compounds
.
9.
1.
1 Physical and chemical properties and uses
9.
1.
1.
1 Physical and chemical properties
The polarity and solubility of non-steroidal anabolic hormones are similar to those of ASs.
They are colorless crystals or white crystalline powders.
They are fat-soluble compounds with weak or medium polarity.
They are insoluble in water and easily soluble in chloroform , ether, etc.
Medium polar solvent
.
The molecular structure contains a long conjugated system composed of phenolic hydroxyl group and carbon-carbon double bond, ketone group and phenolic hydroxyl group, so it can be dissolved in dilute alkali solution, has strong UV absorption at 240-300nm, and individual compounds have fluorescent properties
Stilbene as nonsteroidal anabolic synthetic nonsteroidal estrogens, including diethylstilbestrol (diethylstilbestrol, DES), hexoestrol (hexestrol, HES), diene female phenol (dienestrol, DIS), butene Estrol (dimethylstilbestrol, DMS) and so on
.
At present, the most widely used synthetic estrogen in China is DES, which was first successfully developed at the University of London in 1938
Table 9-1 Physical and chemical properties of common stilbene non-steroidal anabolic hormones
The polarity and solubility of RALs non-steroidal anabolic hormones are similar to those of steroidal anabolic hormones.
They are insoluble in water and easily soluble in medium polar solvents such as chloroform and ether
.
The molecular structure contains a long conjugated system composed of carbon-carbon double bonds, ketone groups and phenolic hydroxyl groups, which dissociate under strong alkaline conditions
Table 9-2 Physical and chemical properties of common RALs non-steroidal anabolic hormones
