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    Home > Active Ingredient News > Drugs Articles > Phytoplankton sampler for air cleanliness testing

    Phytoplankton sampler for air cleanliness testing

    • Last Update: 2022-10-12
    • Source: Internet
    • Author: User
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    Phytoplankton sampler for air cleanliness testing Plankton sampler is suitable for air microbial detection in pharmaceutical GMP plants, dairy plants, hospital operating rooms, biological cleaning, fermentation industry and other clean rooms and sterile environments, as well as air microbial sampling research in relevant research
    and teaching departments 。 As a commonly used detection instrument, it can accurately reflect the concentration of microorganisms in the clean room, with the advantages of large sampling volume, stable performance, easy operation, etc.
    , it is designed according to the principle of particle impact and isovelocity sampling theory, sampling direct, sampling mouth wind speed and clean room wind speed is basically consistent, can accurately reflect the microbial concentration in the clean room, sampling, dust bacteria air through the micropores at high speed, is hit on the agar surface in the Petri dish, these living microorganisms in the culture process, dynamic rehydration process, Grow at high speeds for fast results
    .
    Food safety, medical safety and other matters related to the vital interests of people's livelihood are getting more and more attention from everyone, so there are high requirements
    for production enterprises and public institutions.
    Among the more stringent in the standards of manufacturing enterprises is the "Good Manufacturing Practice for Drugs" of pharmaceutical enterprises, referred to as GMP standards
    .
    Among them, the biological cleanliness requirements in the air cleanliness of the production workshop require the detection of plankton bacteria projects and sedimentation bacteria projects
    at the same time.
    Other food factories, infant formula dairy plants, hospital operating rooms, fermentation industrial clean rooms, etc.
    are also slowly moving
    from a single detection of sedimentary bacteria to a strict GMP standard for the simultaneous detection of plankton bacteria and sedimentary bacteria in both directions.
    We know that bacteria cannot exist alone in the air, and often attach to the surface of dust particles that are several times larger than them, so bacteria
    suspended in the air or settled on the ground.
    In fact, it is a biological particle that carries bacteria, so the relationship between planktonic bacteria and sedimentary bacteria is the relationship between
    planktonic biological particles and settled biological particles.
    Although the concentration of particles (including biological particles) in the natural atmosphere varies with time and place, the particle size distribution is roughly the same
    .
    Therefore, it can be considered that in the windless natural atmosphere, planktonic bacteria and sedimentation bacteria have a correlation, and the concentration
    of plankton bacteria can be calculated by using the value of sedimentation bacteria.
    However, in the biological clean room, the particle size distribution of the fungal particles is different from the distribution in the natural atmosphere, and there is the influence of the air current, and the relationship between plankton bacteria and sedimentation bacteria is inevitably different from the situation
    in the natural atmosphere.
    The internal conditions of biological cleanrooms for different purposes are different, and the relationship between planktonic bacteria and sedimentation bacteria cannot be consistent
    .
    For pharmaceutical biological clean rooms, its production characteristics not only make it different from other uses of biological clean rooms, but also the production of different types of drugs in the clean workshop, the process is different, so can not follow the general biological clean room plankton bacteria and sedimentation bacteria relationship to reflect the relationship between
    the two in the pharmaceutical biological clean room 。 Through the plankton sampler to plant plant to do plankton bacteria and subsidence bacteria sampling experimental data can be drawn: different types of biological clean pharmaceutical workshop, the relationship between the concentration of planktonic bacteria and the number of settled colonies is related to their specific production process, airflow tissue form, number of air changes, personnel situation and other factors, and the difference is very large, it is difficult to find common laws, the relationship between the two control indicators in the GMP Design Code fully reflects this
    。 Therefore, in the general sense, due to the uncertain relationship between the concentration of planktonic bacteria and the number of sedimentation colonies, the amount of sedimentation bacteria in the pharmaceutical workshop can only indicate the contamination status of microorganisms on its surface; Plankton volume reflects the concentration
    of biological particles in the air in the workshop.
    To fully reflect the degree of microbial pollution in the workshop, it is necessary to detect two indicators of sedimentation bacteria and planktonic bacteria at the same time, so for food factories, dairy factories, operating rooms, fermentation industrial clean rooms, etc.
    , for air cleanliness testing, it is necessary to detect two indicators
    of plankton bacteria and sedimentary bacteria at the same time.
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