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For thousands of years, the cannabis plant has been used for recreational and medicinal purposes throughout the world.
Starting from October 17, 2018, recreational marijuana is officially recognized by law in Canada.
Among the cannabinoids found in cannabis plants, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the main active ingredients and are generally considered to be medicinal.
Among the cannabinoids found in cannabis plants, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the main active ingredients and are generally considered to be medicinal.
Age-related changes in pharmacodynamics and pharmacokinetics, as well as the high prevalence of comorbidities and the use of multiple drugs in the elderly, means that their safety and tolerance to cannabinoids may be different.
Recently, experts from the Center for Neuropsychiatric Research at King’s University in the United Kingdom conducted a systematic review and meta-analysis of the safety and tolerability of cannabis-based drugs (CBMs) in adults ≥50 years of age.
Researchers used MEDLINE, PubMed, EMBASE, CINAHL PsychInfo, Cochrane Library and ClinicalTrials.
A total of 46 RCTs were identified as suitable for inclusion, of which 31 (67%) were conducted in the UK and Europe.
Compared with the control group, CBMs containing THC significantly increased the incidence of all-cause and treatment-related adverse events (AEs).
Pure THC increased the incidence of all-cause AEs by 42% and 60% of treatment-related AEs (IRR=1.
At the same time, the THC:CBD combination significantly increased the risk of 40% AE-related withdrawal, but THC alone had no such effect .
THC:CBD combination significantly increases the risk of 40% AE-related withdrawal, but THC alone has no such effect.
CBMs are generally safe and acceptable for the elderly.
references:
plos.
plos.
org/plosmedicine/article?id=10.
1371/journal.
pmed.
1003524" target="_blank" rel="noopener">Safety and tolerability of natural and synthetic cannabinoids in adults aged over 50 years: A systematic review and meta-analysis.
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