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    Home > Active Ingredient News > Endocrine System > PLOS Medicine: Obesity is the main cause of cancer. The higher the BMI, the greater the risk of cancer

    PLOS Medicine: Obesity is the main cause of cancer. The higher the BMI, the greater the risk of cancer

    • Last Update: 2021-12-27
    • Source: Internet
    • Author: User
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    Obesity is one of the ten chronic diseases identified by the World Health Organization.
    1.
    9 billion adults worldwide are overweight and 600 million people are obese
    .


    In China, there are over 300 million people who are overweight and obese


    In fact, obesity is both a feature and a disease
    .


    Obese people are more likely to suffer from diabetes, cardiovascular disease and chronic kidney disease


    Although China is not the country with the highest proportion of obese people, due to its huge population base, China has become the country with the largest number of obese people in the world in recent years
    .

    Recently, researchers from the University of Cambridge in the United Kingdom published a research paper titled " Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study " in the journal " PLOS Medicine " .

    PLOS Medicine Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study

    The study shows that for every additional unit of BMI, the possibility of tumors in the stomach or liver will increase by 13%, the risk of esophageal cancer will increase by 10%, and the risk of lung cancer will increase by 8%
    .

    In the study, the researchers analyzed 367,561 participants in the UK Biobank, a biomedical database, including 19,825 women and 168,736 men
    .


    A BMI over 25 is considered overweight, and a BMI over 30 indicates obesity


    Studies have found that for every unit increase in BMI, several types of digestive system cancers increase in proportion to it
    .

    Specifically, the risk of stomach cancer and liver tumors will increase by 13%, the risk of esophageal cancer will increase by 10%, the risk of pancreatic cancer will increase by 6%, and the risk of lung cancer will increase by 8%
    .

    The relationship between BMI and cancer in general and specific parts of the body

    The relationship between BMI and cancer in general and specific parts of the body

    For gender-specific cancers, each increase in BMI increases the risk of uterine cancer by 10%, and the risk of ovarian cancer and cervical cancer increases by 4%
    .

    On the whole, when cancers are divided into digestive system cancers and non-digestive system cancers, BMI is positively correlated with digestive system cancers, but has nothing to do with non-digestive system cancers
    .

    Interestingly, it reduces the risk of breast cancer in women by 1% and the risk of prostate cancer in men by 3%
    .


    Obesity seems to have a protective effect on sex-specific cancers


    In this regard, the researchers said that the link between obesity and gender-specific diseases may be driven by the production of reproductive hormones in adipose tissue
    .

    The relationship between height and cancer in the whole and specific parts of the body

    The relationship between height and cancer in the whole and specific parts of the body

    In addition, the study also found that height is associated with an increase in overall cancer risk, and the increase in height seems to have a consistent effect on overall and specific areas of cancer
    .

    The researchers emphasized that this result has important clinical significance.


    Although the findings support the causal role of obesity in driving and preventing certain cancers, the different effects of BMI on different malignancies need to be further explored


    In summary, the research results show that fat is the main risk of digestive system cancer, it also affects certain types of cancer, but not all cancer risk factors
    .


    Body fat may play a role in the development of certain cancers, and further research should be done to determine future cancer prevention goals


    Original source:

    Mathew Vithayathil, Paul Carter, Siddhartha Kar, et al.


    Body size and composition and risk of site -specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study in this message
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