PLOS ONE: Eating junk food "steals" memories?

"junk food" (
junk food
), which is rich in sugar and fat, strongly interferes with the learning and memory functions of humans and rodents. Given that obesity has become an epidemic and is associated with impaired cognitive function, it is important to understand the long-term effects of a high-fat diet (
high-fat diet
,
HFD
) on the hippoc body, a key structure in the brain that participates in learning and memory processes, especially in children and adolescents.
27,
, in a study published in
PLOS ONE
, researchers at the University of South Carolina Medical University investigated the effects of
HFD
on sea horse function and whether dietary changes could save short- and long-term effects. The researchers fed the mice normal or high-fat foods. Using the new Object Recognition (
Novel Object Recognition
,
NOR
) experiment
and the

Morris Water Maze
,
MWM
) experiment, the researchers observed that obese mice showed severe memory loss. They can't distinguish objects or recall spatial references.interesting is that once these mice are re-fed to a normal and healthy diet, the harmful effects of these
HFD
on memory can be completely removed. The results strongly suggest that cognitive impairments caused by "junk food" may be reversed in some way.to gain a deeper understanding of the cellular and molecular mechanisms behind "junk food"-induced cognitive decline, the authors studied insulin signaling pathfles and their brains. Previous studies have shown that
HFD
is associated with external insulin resistance, which is associated with hyperinsulinemia (
hyperinsulinemia
) and
InsR
(
Insulin Receptor
, insulin receptor). Specifically,
HDD
is associated with insulin resistance in a variety of key areas of the brain, including the hypothethych, cerebral cortical, and hippoc mark. However, it remains unclear whether these changes are reversible.the study first reported that dietary interventions improved impaired haima insulin signals, but did not reverse
ininsR
expression. Dr
Catrina Sims-Robinson
, who led the study, said: "The
InsR
expression reduction in the
HFD
-induced sea horse may be a protective mechanism against overactivation and desensitization of insulin signals

. Scientiststhat there are likely to be multiple molecular path paths linked to the mechanisms behind dietaryly induced cognitive changes, in which insulin may play an important role. In this study,
Sims-Robinson
and his colleagues demonstrated that dietary interventions can improve impaired glucose tolerance, haima insulin signals, and cognitive impairment. The authors added: "Enhancing insulin signals has welcome therapeutic benefits for improving cognition, but more research is needed to explore its effects on endoplastic stress and inflammation." ”