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    Home > PLoS One: Why are more than 30000 published research results invalid?

    PLoS One: Why are more than 30000 published research results invalid?

    • Last Update: 2017-10-22
    • Source: Internet
    • Author: User
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    Twelve years ago, Professor John Ioannidis of Stanford University published a blockbuster article in the journal PLoS Medicine, discussing why most of the research findings published in the journal were wrong, and this article was viewed more than a million times Recently, Willem halffman and serge horbach of the University of radbold in the Netherlands published their new research in PLoS One: in the past few decades, due to a large number of defective data and systematic errors, many biochemical related research results are likely to be invalid The distribution of original documents affected over the years (source: PLoS One) "honest" mistakes Willem halffman and serge horbach checked the register of misidentified cell lines on the international cell line Authentication Committee Lines) found that 451 cell lines in this list were contaminated by other kinds of cells during the research process What's worse, without knowing it, these cells have been used in more than 33000 published academic studies, the earliest of which can be traced back to the 1950s According to serge horbach, it's a mistake, but not a lie, that most scientists don't intentionally use the wrong cells to make new discoveries However, the key problem is that the research data may not be valid or repeated What's more, we've known that mistakes in cell identification have been going on for half a century, but many scientists still don't realize them New articles using wrong cell lines are published every week in the journal The source of the error is the 451 affected cell lines, the most famous source of pollution is HeLa cells, named after Henrietta lakes In 1951, the 31 year old woman with five children died of cervical cancer Cell biologist George Otto gey found that cancer cells collected from Henrietta can live forever and grow indefinitely in the laboratory Therefore, HeLa cell lines became the first kind of immortal cell lines, that is to say, they will not die because of cell aging For decades, HeLa cells have been contaminating other cell cultures Moreover, a similar situation is not limited to HeLa cells Researchers have found that more than 451 cell lines have been completely absorbed by other cells Therefore, a large number of cell cultures have been mislabeled in previous generations and storage As a result, when scientific articles were published, researchers did not even know that they had made a mistake Over the years, in order to prevent cross contamination of cultured cells more actively, scientists have taken various preventive measures, such as stricter operation manual and better super clean platform Scientists can conduct genetic tests before their research begins to prevent misidentification of cells But it will take more time and money But often the problem is that before the laboratory, the cell distribution center undoubtedly has an important responsibility, because this is where many researchers get cells Of course, the staff of these centers realized the seriousness of the problem earlier than the scientists, they made a statement, but few people would pay enough attention Other cell companies have declined to give scientists additional information because of concerns about the economy and credibility Halffman and horbach said the scientists they spoke with thought that if we wanted to solve the problem, reducing the pressure of publishing articles, or requiring all researchers to conduct gene testing before using cells, would be two feasible ways Halffman and horbach agree They also believe that at this stage, publishers should make a statement for more than 30000 research papers, indicating that the author reported the wrong cell line Then it's up to the reader to decide whether it's a big problem, because sometimes these mistakes don't matter Paper link: http://journals.plos.org/plosone/article? Id = 10.1371/journal.pone.0186281
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