PLoS Pathog: Antifellar vaccine helps protect against Staphylococcus infection.

AUGUST 21, 2020 /--- -- Dr. David Underhill of the Cedars Medical Research Center recently published a study in the journal PLOS Pathogens using staphylococcus alycobacteria (S. A vaccine made up of fungal particles of the aureus protein immunized mice to protect them from Staphylococcus aureus infection.
(Photo: www.pixabay.com) Staphylococcus aureus is one of the most common bacterial infections in the world, and antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) are a major threat and burden to public health.
MRSA not only infects patients with low immune function, but also healthy individuals.
Staphylococcus acobacteria vaccine has failed in clinical trials, and the reasons for this are still unclear.
as the pathogen continues to spread rapidly around the world, it is critical to develop new Staphylococcus acolytic vaccination methods.
with low immune function, such as HIV patients, are highly sensitive to Staphylococcus acobacteria infection and have an increased risk of fungal infections.
based on this evidence, Underhill and colleagues tested whether the stimulation of antifultic immunity promoted the immune response required by an effective host against Staphylococcus auspicrus.
researchers have developed a new vaccine called 4X-SA-GP, which consists of fungal beta-glucosaccharide particles with four Staphylococcus auspicrus proteins.
gave mice a 4X-SA-GP once a week for three weeks, followed by Staphylococcus austratic staphylococcus a disease four to eight weeks later.
results show that vaccine-induced protective T-cell and antibody responses, especially T-cell reactions, are critical to the protection of vaccine-induced Staphylococcus acolyte infection.
, eight weeks after immunity, detectable antibody tests appeared in mice and levels of Staphylococcus austratic bacteria in the spleen and kidneys decreased.
authors believe the work potentially expands the use of beta-glucosin-particle vaccine systems in urgently needed vaccines against Staphylococcus auspicrus.
(bioon.com) Source: Vaccine that harnesses antifungal immunity protects mice from the original source: Paterson MJ, Caldera J, Nguyen C, Sharma P, Castro AM, Kolar SL, et al. (2020) Harnessing antifungal immunity in pursuit of of a Staphylococcus aureus vaccine strategy. PLoS Pathog 16 (8): e1008733. doi.org/10.1371/journal.ppat.1008733.