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Speaking of AIDS, everyone has heard of it.
According to WHO, at the end of 2019, there were an estimated 38 million people living with HIV .
infection
WHO
WHO WHOEvery year, more than 150,000 babies worldwide are infected with HIV in the womb, at birth or through breastfeeding.
immunity
Recently, a team at the Weill Cornell Medical Children’s Center in New York, USA, discovered that mother-to-child transmission of HIV is related to rare virus variants in the mother’s blood that can evade generalized neutralizing antibodies (bnAbs), which can be used to prevent multiple HIV strains.
child
In this study, the researchers isolated HIV variants that were transmitted from mother to baby, and amplified the HIV-1 envelope gene (env) by single-genome amplification.
Characteristic sequence analysis showed that the theme enriched in the env sequence of the spreading mother was related to the resistance of generalized neutralizing antibody ( bnAb ).
The spread of enrichment in the mother's enrichment in the dissemination of mother env env sequence of themes and broad neutralizing antibodies ( bnAb sequence of topics and broadly neutralizing antibodies ( bnAb ) resistance related.
At the time of childbirth, the circulating mother virus is resistant to bnAb bnAb- mediated neutralization at the time of childbirth , but has no resistance to autogenous plasma neutralization, which indicates the risk of mother-to-child transmission increase.
Neutralization sensitivity of infant and mother Env variants to a group of bnAbs .
Neutralization sensitivity of infant and mother Env variants to a group of bnAbs .
The study author, Dr.
Literature reference:
Amit Kumar, Elena E.
plos.
org/plospathogens/article?id=10.
1371/journal.
ppat.
1009478">doi: 10.
1371/journal.
ppat.
1009478.
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