PNAS: a mechanism that individually regulates the release and circulation of synaptic vesicles

Chemical synapses transmit information in the nervous system

Coexistence of different types of voltage-gated calcium channels in presynapses 

At the chemical synapse, the incoming electrical impulse is converted into a chemical signal, which is transmitted to the next cell

By combining the genetic modification of the Drosophila genetic model organism neuromuscular synapse with electrophysiological and photophysiological measurements, the research team was able to prove that presynapses contain two different types of voltage-gated calcium channels, namely Cav2 and Cav1

Separate the functions of Cav1 and Cav2 by calcium pump 

A key question is how calcium signals are functionally separated at the nanoscale of the presynaptic terminal through different channels, because calcium is a highly diffuse intracellular messenger after all

Calcium channels and the regulation of important synaptic functions 

In the future, Duch's and Heine's research team will continue to explore the presynaptic interactions between calcium channels and related molecules

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