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According to a recent study, UT Southwestern researchers reported that a class of antibiotics that have been used for decades can prevent pain caused by nerve damage in an animal model.
More than 100 million Americans are affected by chronic pain, and a quarter of them suffer from pain every day.
To treat chronic pain, the prescription of opioid analgesics has increased exponentially since the late 1990s, leading to an increase in abuse and overdose.
The study leader, Dr.
The research team focused on EphB1, a protein found on the surface of nerve cells.
To explore further, Ahmed used a computer model to scan the FDA-approved drug library to test whether its molecular structure has the correct shape and chemical properties to bind EphB1.
In order to study whether these drugs can bind to EphB1 and inactivate EphB1, the research team combined the protein with these drugs in a petri dish and measured the activity of EphB1.
In three different neuropathic pain mouse models, the combined injection of these three drugs significantly reduced the response to painful stimuli such as heat or pressure, and the triplet was more effective than each drug at lower doses Separately big.
She said: “Unless we can find alternatives to opioids to treat chronic pain, we will continue to see a spiraling trend in the popularity of opioids.
Information source: Three longtime antibiotics could offer alternative to addictive opioid pain relievers
Original source: Mahmoud S.