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At the Japan Cancer Research Foundation (JFCR), scientists discovered that non-coding RNA (ncRNA) comes from repetitive elements around the center point, which can trigger inflammatory gene expression during aging and cancer
Aging is an essentially irreversible cell cycle arrest state, caused by a variety of stressors, namely aging, obesity, radiotherapy and chemotherapy
The regulatory mechanism discovered by the JFCR researchers is described in detail in an article (" Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer "), which was published this week in the Proceedings of the National Academy of Sciences.
The author of the article wrote: “Because CTCF blocks the expression of ncRNA around the central point in young cells, the down-regulation of CTCF during cell senescence triggers the up-regulation of ncRNA and sasp-related inflammatory gene expression
To get these findings, JFCR researchers used next-generation sequencing technology to analyze genome-wide chromatin interactions and gene expression
In addition, JFCR researchers have observed that the expression of non-coding RNA (hSATII RNA) is significantly up-regulated during cell aging
"Interestingly, the content of hSATII RNA in small EVs from senescent cells is higher than that in small EVs from proliferating cells," the author of the article pointed out
In addition, the researchers found that hSATII RNA can be highly detected in cancer cells in surgical specimens of patients with primary colon cancer
Scientists at JFCR concluded: “These findings highlight the new role of hSATII RNA, which supports tumor development in a non-cell-autonomous manner by secreting sasp-like inflammatory factors and small EVs