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PNAS: cGAS limits the development of colon cancer by protecting the integrity of the intestinal barrier

 Last Update: 2021-06-28
 Source: Internet
 Author: User

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The DNA-sensitive enzyme cyclic guanosine monophosphate-adenosine monophosphate synthase (CGAS) regulates inflammation and immune defense against pathogens and malignant cells

Colorectal cancer is one of the most common malignant tumors and the main cause of cancer deaths in men and women

Cyclic guanosine monophosphate synthase (cGAS) is a DNA sensor that can trigger innate immune responses

In this study, the authors used dextran sodium sulfate (Dss)-induced colitis model and colitis-associated colon cancer (Cac) model to study the role of cGAS in colitis

The intestinal barrier plays a key role in maintaining the health of the body

Reference

Shuiqing Hu et al.

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