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    Home > Active Ingredient News > Study of Nervous System > PNAS: For the first time in humans, using a new type of magnetoencephalogram to visualize fast brain signals

    PNAS: For the first time in humans, using a new type of magnetoencephalogram to visualize fast brain signals

    • Last Update: 2021-05-08
    • Source: Internet
    • Author: User
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    magnetic field

    magnetic field magnetic field

    Information processing inside the brain is one of the most complex processes in the human body.


    Interruption of this process usually leads to severe neurological disorders.
    Therefore, studying the signal transmission inside the brain is the key to understanding countless diseases.
    However, from a methodological point of view, it is difficult to study the signals inside the brain.


    Information processing inside the brain is one of the most complex processes in the human body.


    The brain uses both slow current and fast current to process information.


    At this stage, scientists use two methods , electroencephalogram (EEG) and magnetoencephalogram (MEG), to visualize brain activity from the outside of the skull.


    Recently, a research team from Charité-Universityätsmediz and Physikalisch-Technische Bundesanstalt (PTB) in Berlin used a new and particularly sensitive MEG device to successfully visualize these fast external brain signals for the first time and found an amazing degree of variability.


    Comparison of the amplitude spectral density recorded in the resting state and the system noise without subject

    Comparison of the amplitude spectral density recorded in the resting state and the system noise without subject

    In order to eliminate external interference sources such as power networks and electronic components, the research was conducted in the shielded room of PTB .
    The researchers electrically stimulated specific nerves on the wrists of four healthy subjects, and placed MEG sensors on the hands responsible for processing.
    Right above the area of ​​the brain that feels stimulus.

    In order to eliminate external interference sources such as power networks and electronic components, the research was conducted in the shielded room of PTB .
    The researchers electrically stimulated specific nerves on the wrists of four healthy subjects, and placed MEG sensors on the hands responsible for processing.
    Right above the area of ​​the brain that feels stimulus.

    The study found that after subjects undergoing electrical stimulation, a small group of simultaneously activated neurons in the cerebral cortex generates action potentials in response to individual stimuli.
    These fast currents change with each stimulus, and these changes are also independent of the slow currents.
    Although the stimuli for the brain and the hand are the same, there are huge differences in the way the brain processes information related to the touch of the hand.

    The study found that after subjects undergoing electrical stimulation, a small group of simultaneously activated neurons in the cerebral cortex generates action potentials in response to individual stimuli.
    These fast currents change with each stimulus, and these changes are also independent of the slow currents.
    Although the stimuli for the brain and the hand are the same, there are huge differences in the way the brain processes information related to the touch of the hand.

     

     

    A and B: average somatosensory evoked response; C and D: average phase-locked and insensitive time-frequency (TF) representation of magnetoencephalogram response; E: and excess analysis of variance of single test response; example of subject S1 data.

    A and B: average somatosensory evoked response; C and D: average phase-locked and insensitive time-frequency (TF) representation of magnetoencephalogram response; E: and excess analysis of variance of single test response; example of subject S1 data.

    This research is the first non-invasive method to observe the response of nerve cells in the brain to a single sensory stimulus.
    To the extent to which factors such as alertness and fatigue affect the processing of information in the brain.
    If at the same time receive additional stimulus and other research difficulties, open up new paths.
    Lay the foundation for highly sensitive MEG technology.
    To help scientists better understand neurological diseases related to rapid brain signal interruption, such as medsci.
    cn/course/search.
    do?w=%E7%99%AB%E7%97%AB">epilepsy and Parkinson's disease, and better treat them.

    It is the first time to observe the response of nerve cells in the brain to a single sensory stimulus in a non-invasive way.
    To the extent to which factors such as alertness and fatigue affect the processing of information in the brain.
    If at the same time receive additional stimulus and other research difficulties, open up new paths.
    It is the first time to observe the response of nerve cells in the brain to a single sensory stimulus in a non-invasive way for high sensitivity .
    To the extent to which factors such as alertness and fatigue affect the processing of information in the brain.
    If at the same time receive additional stimulus and other research difficulties, open up new paths.
    Lay the foundation for highly sensitive MEG MEG technology.
    To help scientists better understand neurological diseases related to rapid brain signal interruption, such as medsci.
    cn/course/search.
    do?w=%E7%99%AB%E7%97%AB">epilepsy and Parkinson's disease, and better treat them.
    Technology lays the foundation.
    Help scientists better understand and treat neurological diseases related to rapid brain signal interruption, such as medsci.
    cn/course/search.
    do?w=%E7%99%AB%E7%97%AB">epilepsy and Parkinson's disease.
    medsci.
    cn/course/search.
    do?w=%E7%99%AB%E7%97%AB">epilepsy

    Dr.
    Waterstraat of the Department of Neurology of Charité University said that so far, research can only observe fast current signals when nerve cells are receiving information, instead of transmitting information to obtain fast current signals when responding to a single sensory stimulus.

    Dr.
    Waterstraat of the Department of Neurology of Charité University said that so far, research can only observe fast current signals when nerve cells are receiving information, instead of transmitting information to obtain fast current signals when responding to a single sensory stimulus.


    Original source:

    Original source:

    Gunnar Waterstraat,Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes.


    Doi: 10.
    1073/pnas.
    2017401118

    Doi: 10.


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