PNAS interpretation! Hydrogen sulfide may be effective against Alzheimer's disease!

In a recent study published in the international journal Proceedings of the National Academy of Sciences entitled "Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydration GSK3 beta and inhibiting Tau hyperphosphorylation", scientists from institutions such as the University of Exeter in the United Kingdom found that hydrogen sulfide could help prevent Alzheimer's disease effectively.
Hydrogen sulfide is typically characterized by the toxic, corrosive and smell of rotten eggs, and its "notorious" may soon improve, and after studying mice, the researchers found that the odor of hydrogen sulfide may help protect the body's brain cells from Alzheimer's disease, a bio-reaction that could help researchers develop new drugs to fight neurodegenerative diseases.
researcher Bindu Paul said: 'Our latest findings use hydrogen sulfide and other gas molecules in cells to firmly link the body's aging, neurodegenerative cell signals; normally the body produces a small amount of hydrogen sulfide to help regulate the body's cells. Metabolism to dilation of blood vessels and other systemic functions, gas is the main cell messenger molecule, which is particularly important for brain health, however, unlike traditional neurotransmitters, gas is not stored in the vesicles, it will be through different mechanisms to quickly promote cell signaling to play a role.
hydrogen sulfide, for example, needs to modify the targeted protein through a chemical vulcanization to regulate its activity.
In previous studies, researchers used a new method to reveal that levels of sulfhydration in the brain decrease with age, a trend that is magnified in the brains of Alzheimer's patients;
In the current study, researchers studied genetically engineered mouse models that simulated Alzheimer's disease in humans, injecting mice with a hydrogen sulfide-carrying compound called NaGYY that slowly releases "passenger" hydrogen sulfide molecules while "traveling" through the body;
's behavioral studies of mice showed that hydrogen sulfide improved the cognitive and motor function of the injected mouse body by 50 percent compared to mice without the injection compound NaGYY, and that the injected mice were also better able to remember where the platform exit was located and were more active than mice that did not receive the injection (simulated Alzheimer's disease). So far, researchers lack pharmacological tools to simulate how slowly the body produces trace amounts of hydrogen sulfide gas in cells, said professor Matt Whiteman, a
researcher, and the compounds used in the study found that it corrects levels of hydrogen sulfide in the brain, successfully reversing some aspects of Alzheimer's disease.
results suggest that the introduction of hydrogen sulfide may reverse the behavioral outcomes of Alzheimer's patients, but researchers hope the study will shed light on how the brain reacts chemically to gas molecules.
A series of biochemical experiments have revealed that a common enzyme called GSK3 beta (Gsk3 synthase β) may change, and in the presence of healthy levels of hydrogen sulfide, GSK3 beta usually acts as a signaling molecule, adding chemical markers to other proteins and altering their function, but the researchers observed that GSK3 beta is over attracted to another type of brain called Tau protein without hydrogen sulfide.
When GSK3 beta interacts with the Tau protein, Tau transforms into another form, forming entanglements and aggregations within nerve cells, and as Tau accumulates, tangled proteins block communication between nerve cells, ultimately promoting nerve cell death, which eventually leads to the deterioration and eventual loss of the body's cognitive, memory and motor functions, which are often the main features of Alzheimer's disease. Daniel Giovinazzo, a
researcher, said understanding the mechanisms by which this series of events occur is important in designing interactions that block interactions such as natural hydrogen sulfide; the next step is to use a joint study to illustrate how sulfur-based groups interact with GSK3 beta and proteins involved in other cell and organ systems that are pathologically altered, and to analyze whether this new hydrogen sulfide delivery molecule can be the focus of next research.
: Daniel Giovinazzo, Biljana Bursac, Juan I. Sbodio, et al. Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation, Proceedings of the National Academy of Sciences (2021). DOI:10.1073/pnas.201722518Hydrogen sulfide can guard against Alzheimer's Diseaseby University of Exeter This article was originally sourced from Bio Valley, for more information please download BioGuani APP (