PNAS: Intestinal Host-Microbiological Balance Regulation during Tumor Occurrence

In all animals, the intestinal epithelial forms a tight environmental barrierThe intestinal epithelial regulates the absorption and immune response of nutrients and prevents systemic infectionrecently, researchers used a model of intestinal tumors in fruit flies to study the effects of tumor development on the microbiomeresearchers found that after the loss of BMP signal transduction, tumors led to abnormal activation of JNK/Mmp2 signal transduction, followed by intestinal barrier dysfunction and symbiotic imbalancein turn, the dysfunctional microbiome triggers a regenerative reaction that stimulates tumor growthresearchers also found that inhibiting the transduction or depletion of the Microbiome of JNK signals restores the barrier function of intestinal epithelial cells, leading to the reconstruction of the host-microbiological balance and prolonging the life of the bodythe experiment found a JNK-dependent feedback amplification cycle between the intestinal tumor and the microbiomeThe researchers also stressed the importance of controlling the activity levels of JNK signal transduction to maintain epithelial barrier function and host-microbial balance