PNAS: Noise affects the learning and memory function associated with the sea horse

The impact of noise pollution on human health with industrialization has received more and more attention.
previous studies have confirmed that noise has a significant negative impact on the function of auditory systems in humans and animal models, but the effects of noise on non-auditory functions, especially brain learning and memory, and their mechanisms have not been studied in detail.
Xiaoming Zhou, a team of professors at the School of Life Sciences of East China University and the Key Laboratory of the Ministry of Brain Functional Genomics, recently published academic results in the Proceedings of the National Academy of Sciences (PNAS), Zhang et al., Environmental noisees degrade hippocampus-learning and memory. Proc Natl Acad Sci USA.2021 Jan 7;118:e2017841117) shows that early post-birth noise exposure significantly reduces learning and memory function associated with the brain region of the sea horse in rats.
noise exposure simultaneously inhibits the induction of the long-range enhancement effect of the sea horse and lowers the total amount of expression or phosphorylation level of some key signal molecules associated with long-range enhancement induction in the sea-horse synapses.
these findings from rodent models suggest that early-life ambient noise may impair learning and memory function associated with the brain region of the sea horse by altering the plasticity of synactal transmission.
Zhang Yifan, a postdoctoral student with Professor Zhou Xiaoming, is the first author of this thesis, and the East China Division is the first completion unit.
the research was supported by the National Natural Science Foundation of China, the Science and Technology Innovation and Intelligence Program of colleges and universities, and the basic research project of the Shanghai Science and Technology Commission.
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