PNAS: Nuts help repair damaged nerves.

19, 2020 /--- -- A chemical compound found in cashew nuts could promote the repair of myelin, according to a recent paper published in the journal PNAS by a team of researchers at De Bealt University Medical Center.
myelin is the protective crucible around the nerves.
destruction of this mules (demyelination) is a sign of multiple sclerosis and diseases associated with the central nervous system.
Subramaniam Sriram, a professor of neurology and senior author of the paper, said: "We believe this is an exciting discovery that offers new avenues for finding treatments to correct MS and other demyelination diseases.
led by Sriram (Photo: www.pixabay.com) has shown that a protein called leucocyte interleulin 33 or IL-33 induces myelin formation.
IL-33 is an immune response regulator, and multiple sclerosis is an autoimmune disease.
isolated from cashew shells are called acadyna acids.
Sriram and the team were interested because it was known to inhibit an enzyme involved in gene expression called hismoglobin acetyl transferase or HAT, and the team found that any enzyme that inhibited HAT could induce IL-33 production.
report includes a series of new findings that suggest that deaminate can be used for potential therapeutic uses of demyelinating disease.
In-body, adding the compound to the rat cells most responsible for myelin formation (less protrusive glial cell preloom cells or OPCs) stimulates the induction of IL-33 and rapidly increases the expression of myelin genes and proteins, including increased dose dependence of myelin alkaline proteins;
in animal models treated with the compound, anatomy and electron microscopes show an increase in dose dependence on myelin.
: "These results urge further research into the treatment of acadyna acid for demyelination.
.com Source: Cashew shell compound sees to mendd damage nerves Original source: sa Ljunggren-Rose el al., "Anacardic acid induces IL-33 and promotes remyelination in CNS," PNAS (2020).