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PNAS: Stimulating Signals, Improving Metabolic Health, Treating Obesity

 Last Update: 2022-03-06
 Source: Internet
 Author: User

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Details of the study were published in Proceedings of the National Academy of Sciences, the official journal of the National Academy of Sciences
.

The scientists initially investigated the biological function of HDAC11, a lysine decapsulating enzyme, and determined that deleting it in animal models stimulated brown adipose tissue (BAT) formation
.

Loss of HDAC11 also triggers "whitening," turning white adipose tissue (WAT) into brown-like adipose tissue

BAT and beige WAT are unique forms of fat that are stimulated at low temperatures
.

BAT and beige WAT produce heat and burn calories

"Our new study shows that inhibiting HDAC11 promotes β-AR signaling in adipocytes through a previously unrecognized mechanism, lysine myristoylation
.

The findings suggest that inhibition of HDAC11 enhances adipose tissue GPCR signaling in GPCRs, laying the foundation for developing treatments for obesity and diabetes

"There is a lot of additional work that needs to be done before anything like this can be brought into the clinic," Bagchi added
.

"This paper only describes a second myristoylated substrate for HDAC11

Journal Reference :

Rushita A.

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