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A research team led by Professor Jiyue Zhu from Washington State University School of Pharmacy recently discovered a DNA region called VNTR2-1 that seems to drive the activity of the telomerase gene, which has been shown to prevent certain types of cells Aging
The telomerase gene controls the activity of telomerase.
Understanding how the telomerase gene is regulated and activated, and why it is only active in certain types of cells, may one day become the key to understanding how humans age and how to prevent the spread of cancer
Zhu said that they recently discovered that VNTR2-1 helps drive the activity of the telomerase gene.
"Almost 50% of our genome is made up of repetitive DNA that does not code for proteins," Zhu said
Their findings are based on a series of experiments that found that deleting the DNA sequence of cancer cells—whether human cell lines or mice—can shorten telomeres, cells age, and tumors stop growing
Professor Zhu said: "It's very different.
Since the very short sequence was only found in African-American participants, they observed this group more closely and found that compared with the control group participants, there were relatively fewer centenarians with a shorter VNTR2-1 sequence
"Our findings tell us that the VNTR2-1 sequence contributes to our genetic diversity in aging and cancer," Zhu said
Zhu pointed out that because African-Americans have lived in the United States for several generations, many of them have white ancestors, and they may have inherited some of this genetic sequence from whites
In addition to Zhu, the authors of the paper include Tao Xu and De Cheng, co-first authors of Washington State University, and their collaborators at China Northeast Forestry University, Pennsylvania State University, and North Carolina State University
Tao Xu, De Cheng, Yuanjun Zhao, Jinglong Zhang, Xiaolu Zhu, Fan Zhang, Gang Chen, Yang Wang, Xiufeng Yan, Gavin P.