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    Home > Biochemistry News > Biotechnology News > PNAS: Uncovering molecular mechanisms for the treatment of hypertension by folk herbs

    PNAS: Uncovering molecular mechanisms for the treatment of hypertension by folk herbs

    • Last Update: 2020-06-01
    • Source: Internet
    • Author: User
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    Faced with these conditions, scientists are eager to find new ways to solve the growing problem of high blood pressurethe approximate timeline of human use of buck plants Picture source: Reference s1, a number of scientists have set their sights on the long river, and found that archaeological evidence suggests that these herbs were eaten non-foodily by Homo erectus or similar species as early as 800,000 years agoIn addition, the earliest DNA evidence also shows that The Neanderthals had eaten medicinal plants 48,000 years agoAs for hypertension antihypertensive drugs are also recorded in the history of the art: lavender, fennel and chamomile and other common folk plant-based drugs for their treatment has a real effectwhy do herbs have a bucking effect? What are its specific mechanisms of action? Researchers at the University of California, Irvine, are beginning to look at these questions and try to come up with scientific answersOn September 30th they updated their findings in the international heavyweight journal Proceedings of the National Academy of Sciences (PNAS), saying that the molecular mechanisms of the plant-based drug used to treat high blood pressure had been discoveredhttps://doi.org/10.1073/pnas.1907511116KCNQ5 potassium channel activation is a common molecular mechanism for buck herbs
    Professor Geoff Abbott Picture: UCIIn this experiment, researchers first selected a variety of herbal plants to be randomly selected as subjects, including lavender, fennel, basil, thyme, mayoran and chamomileThen, under Professor Geoff Abbott's leadership, the researchers extracted the plants and identified the common bioactive characteristics of the extractsresults showed that blood pressure increased when the blood vessels contracted, and when they relaxed, blood pressure droppedSurprisingly, these herbs activate a specific potassium channel of KCNQ5 found in the blood vessel smooth muscle, causing the blood vessel smooth muscle to relax and have some reasonable mechanism for buckingIn addition, the researchers tested other plants that have not yet been shown to have buck properties, such as coriander and wheat grass, and found that they did not activate the KCNQ5 potassium channelit's worth noting that while a variety of herbs activate KCNQ5, the level of activation varies from each herb to a differentLavender, fennel seed extract and chamomile were shown in the trial as the most effective activator for kCNQ5 potassium channel Aloperine is the "switch" that activates the KCNQ5 potassium channel
    and then researchers begin a deeper study of which plant compounds play an important role in activating the potassium channel this time, the researchers chose to start with bitter ginseng root, because in the Literature of Traditional Chinese Medicine there is a clear record of bitter ginseng root has the characteristics of bucking pressure and vascular relaxation As a result, the experiment found that a chemical called Aloperine (alkaloid) was present in the bitter ginseng root, which was an important "switch" to activate the KCNQ5 potassium channel conclusion
    the current market of buck drugs are not targeted at the KCNQ5 channel Professor Abbott said the discovery of these plant-based KCNQ5 selective potassium channel openers could help develop targeted treatments for diseases such as hypertension and KCNQ5 dysfunction But we still need to be aware that there are still challenges on the way to the operation of receptor recognition, drug development, and marketing References: s1 s KCNQ5 is a unifying molecular mechanism shared by genetically and culturally dyweud yn dweud yn dweud siaie dweud s iaai saiaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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