Polymer TESET can both kill bacteria and kill viruses Understand

The development of AMR and antibiotics (Photo: Source: Resources 1)face this problem, in addition to the further development of new antibiotics for patients to effectively treat, through surface disinfection means to block the transmission of pathogens in a timely manner, do a good job of supervision and protection of AMR also has an important preventive effectSurface disinfection methods include physical disinfection and chemical disinfection, which uses ultraviolet radiation, high temperature boiling to kill pathogens, and chemical disinfection involves the use of bleach, hydrogen peroxide and other oxidizing disinfectants, but this method can damage medical equipment and equipment, and sometimes lead to other health problemsMetals (e.gAg, Cu) or metal oxides (e.gZnO, TiO2) nanoparticles are also embedded in polymer materials for disinfection, but the entry of these metal nanoparticles into organisms can lead to bio-enrichment, which can also pose environmental and human health hazardsIn addition, photosensitive agents can also be mixed into polymer molecules, the material in the presence of oxygen under the conditions of visible light excitation can produce a single-line oxygen, thereby achieving the role of sterilization▲(:[2]),(North Carolina State University, Raleigh)Richard JSpontakReza AGhiladi,[-b-(-alt-)-b-()-b-(-alt-)-b-](TESET),,599.9999%。 In addition, this polymer can not only antibacterial, virus also has a good inactivation effectThe results were published in the journal Materials Horizons, a journal owned by the Royal Society of Chemistry (RSC)image source: Reference materials ,teSET molecular structure (image source: reference material s1)some polymer materials can be modified by appropriate functional modification to produce antibacterial effects, the mechanism of which is the material molecular modification of the cation species and the anion species on the surface of the microbial cell membrane electrostatic interaction, thereby inducing cell membrane ruptureThis sterilization method avoids damage to medical devices and equipment without the environmental impactEarly studies show that TESET adjacent structural units are not compatible with thermodynamics, so it can be spontaneously self-assembled into a material with nanostructure, which has good stability and mechanical strength, can be applied to water purification, gas separation and organic solar cells and other fields The author found that the polymer with sulfonated styrene as the intermediate segment, not only overcome the problem of organic polymer hydrophobic, nor because the sulfonization through the high dissolution in water, in the water solution conditions only partially dissolved, hydrogel state, and can maintain mechanical stability In addition, sulfonate group in the water solution can occur ionization, the resulting sulfonate root anion and microbial cell membrane surface carry the same charge, but at the same time the production of hydrated hydrogen ions can significantly reduce the pH of its surrounding environment, thereby increasing the external membrane stress of the microbial cell membrane, prompting its rupture, to achieve the purpose of killing microorganisms the authors prepared two different degrees of sulfonizing TESET, TESET26 with 26 mol and TESET52 with 52 mol% sulfonization, and examined their antibacterial activity using methicillin-resistant Staphylococcus aureus (MRSA) as an example TeSET52, which has a high sulphation, is even better sterilized, killing 99.9999% of MRSA in 5 minutes TESET's antibacterial activity on MRSA (Photo: Source: Resources 2) they further examined the antibacterial effect of TESET against other bacteria, both polymers can kill 99.9999% of the methicillin-sensitive Staphylococcus aureus in 5 minutes, of which TESET26 sterilization is better In addition, both have a good killing effect on vancomycin-resistant enterococci (VRE) teset inhibits different Gram-positive and negative bacteria (Photo: Resources 2) TESET is not only effective for Gram-positive bacteria, but also has good inhibition of Gram-negative bacteria Bowman's bacteria, clyfipneumonia and E coli can all be effectively killed under the action of TESET26 and TESET52 Mr MRSA, VRE, Bowman, and Klebper, four members of the six superbugs (ESKAPE), are highly resistant to most existing antibiotics the polymer not only kills bacteria, but also resists viral microorganisms, showing broad-spectrum antimicrobial properties Blisteral oral inflammatory virus (VSV), influenza A virus can be effectively inactivated under teSET, human adenovirus 5 (HAd-5) no envelope, so inactivation effect is poor, but TESET52 can still inactivate 99.997% of HAd-5, with 60 minutes of photodynamic inactivation means effect TESET's inactivation effect on the virus (image source: source: reference s.2) the author also pointed out that TESET's sulfonate root can be combined with metal ions to reduce its antimicrobial activity, but the use of hydrochloric acid and even lemon juice and other acids for further treatment, but also can restore its ability to kill pathogens, so that the material can be based on the actual needs of anti-active microorganism regulation Another advantage of TESET is that it is fully recyclable and, once serviced, re-dissolved and cast and molded for recycling purposes In addition, the end of the polymer is hydrophobic, so it can be fixed by physical cross-linking, easy to use based on these advantages, we believe that this polymer is expected to be widely used in biomedical materials, food packaging and smart textiles References Retrieved Aug 14, 2019, from https:// Intherinly Self-steriled Charged Multiblock Polymers that Kill Drug-resistant Microbes in Minutes Mater Horiz., DOI: 10.1039/c9mh00726a Retrieved Aug 14, 2019, from https:// original title: "Both bacteria and viruses, such a pass", to understand