Pomegranate extract and chrysanthemum sugar may be a high-quality cholesterol-lowering combination

researchers believe that a combination of pomegranate extract and chrysanthemum therapy can maximize cholesterol reduction.animal studies have shown that polyphenol-rich pomegranate extracts (
PomX
) and polysaccharide chrysanthemum powders can help mitigate metabolic changes caused by a high-fat diet, but the effects of their binding have not yet been detected., the researchers conducted a study to determine the effects of
PomX
and chrysanthemum powder, either individually or in combination, on cholesterol and lipid metabolism in mice.they divided male mice between
6
and
7
weeks old into
4
groups, all placed in a high-fat, high-sucrose diet: the first group (control group) did not supplement feed, the second group supplemented
PomX
, the third group was chrysanthemum powder, and the last group was
PomX
and chrysanthemum powder.four weeks after , the researchers observed that supplementation with
PomX
and chrysanthemum powder reduced total liver and serum cholesterol in mice, better than adding extracts or polysaccharides alone.PomX
alone increased gene expression of two key regulatory factors in the bile acid synthesis pathway, reducing hepatic triglyceride levels, while chrysanthemum powder had no significant effect on liver or serum triglyceride levels., chrysanthemum powder itself lowers the gene expression of cholesterol synthesis of key regulatory factors from the beginning, increasing the excretion of total bile acid and neutral sterols.only mice
the PomX-
combination of chrysanthemums saw their liver and lipid weight decrease.In addition, the researchers wrote, "When chrysanthemums are combined with
PomX
, the stimulation of the
PomX
-induced main bile acid synthesis pathway remains, and chrysanthemum induction inhibits cholesterol synthesis, but sterol excretion in feces increases."involving intestinal research the researchers wrote, this is the first detailed study to investigate and report on the combination of
POMX
and chrysanthemum supplements to enhance cholesterol-lowering effects.The individual
PomX
lowers cholesterol by increasing bile acid synthesis, but also increases bile acid excretion, which is mainly directed at liver cholesterol synthesis from the beginning, fecal cholesterol and bile acid excretion involving changes in the metabolism of the gut microbiome," they concluded. Adetailed analysis of cholesterol re-absorption and intestinal cholesterol synthesis, as well as the gut microbiome in future studies, will increase our understanding of how
PomX
and chrysanthemum powder regulate the steady state of cholesterol throughout the body. ”