echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Potential new approach to treating diabetes complications

    Potential new approach to treating diabetes complications

    • Last Update: 2022-03-05
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com


    Diabetes is a serious disease that causes blood sugar levels to be too high


    "Hypoxia, which reduces oxygen content in tissues, has also recently been identified as a detrimental factor in diabetes," explains Xiao-Wei Zheng, assistant professor in the Advanced Laboratory at Karolinska Institutet in Stockholm, Sweden


    To answer this question, Zheng, Narayanan, Xu, and colleagues recruited 13 non-smoking volunteers with type 1 diabetes and 11 healthy volunteers


    Since hypoxia in diabetics increases cellular ROS levels, and HIF-1 helps cells respond to hypoxia, the team hypothesized that inhibiting HIF-1 would lead to overproduction of ROS


    Finally, the team demonstrated that restoring HIF-1 function in mice reduced the overproduction of ROS in tissue cells and protected the animals' kidneys from cell death and damage


    "We have shown that inhibition of HIF-1 plays a central role in ROS overproduction and tissue damage in diabetes and is therefore a potential therapeutic target for these complications,





    Magazine

    Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.