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    Home > Biochemistry News > Biotechnology News > Powerful combination! Shenzhen Advanced Institute of the Chinese Academy of Sciences and Sai Lifu (China) jointly solve the problem of aging

    Powerful combination! Shenzhen Advanced Institute of the Chinese Academy of Sciences and Sai Lifu (China) jointly solve the problem of aging

    • Last Update: 2022-10-03
    • Source: Internet
    • Author: User
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    Recently, Celefu (China) and the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences jointly established the Zhongke Celifu Molecular Network Anti-Aging Joint Laboratory (hereinafter referred to as the Zhongke Celery Joint Laboratory), which is committed to establishing an integrated platform for the research and development of aging intervention technology to deeply explore the biological mechanism
    behind aging.


    Through the strong alliance, the two sides will give full play to their respective resource advantages, and carry out extensive and in-depth cooperation around the technology development and application of anti-aging molecule NAD+, the screening of anti-aging substances, the exploration of anti-aging multi-target and other cutting-edge technologies, new product development, technology platform establishment and talent training, etc.


    It is reported that Sai Lifu is a high-tech brand committed to AI multi-target anti-aging, with a strong scientific research team and R & D application platform, which can continuously transform cutting-edge core technologies into health products
    .


    NAD+ is an indispensable coenzyme component in hundreds of enzyme proteins in the human body, dominating hundreds of life activities in the human body, which is essential for regulating cell aging and maintaining normal function of the body, but direct supplementation of NAD+ is difficult to be absorbed by the human body, the efficiency is extremely low, researchers turn to "curve to save the country", study NAD+ precursor substances and other forms
    .


    Qiu Liyang, a doctoral supervisor from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, expressed his views on NMN: "First of all, we must admit that NMN is effective, but we must also admit that some people do not respond to
    NMN.


    Yu Bo mentioned that a clinical trial in the United States in 2021 confirmed that the blood NAD+ level of the experimental subjects after oral NMN was large heterogeneous (1), and in 2022, there were also clinical trial papers in Japan that showed that there were people with weak responses after oral NMN (2), and the latest human clinical trial data for NMN supplementation in Guangzhou Institute of Physical Education, in which Celefu participated, also showed that there were indeed some people who did not respond
    after taking NMN.


    Through in-depth research on this phenomenon, it was found that aging-induced inflammation promotes high expression of CD38 in immune cells, and CD38 reduces the body's absorption level
    of NMN and NAD+ through external enzyme activity.


    Yu Bo introduced that the hydrogenated molecules such as NADH, NRH, and NMNH that enter cells with different pathways from NMN are speculated to be unaffected by CD38 and are potentially more efficient NAD
    + supplementation.


    At present, Celeflex has overcome the problem that NADH is difficult to preserve for a long time, produced a force element that can still ensure stability under storage conditions of up to 3 years (Cele Lifu NADH), and obtained a number of invention patents
    .


    It is understood that the joint laboratory of Zhongke Sailifu Anti-Aging also plans to take "NAD+ detection" as a technological breakthrough, conduct "super clinical trials", and apply the world's first NAD+ probe high-throughput detection technology to deeper research
    on aging.


    The traditional NAD+ detection method requires the use of a large volume, and a single price of more than 700,000 yuan of mass spectrometers and chromatographs, with a professional testing team, three days to get the results
    .


    Before that, aging has no way to measure, so it is difficult to effectively intervene and manage it, supplementing NAD+ as one of the most mainstream aging intervention strategies, the NAD+ high-throughput detection program based on NAD+ probe technology realized by the joint laboratory of Zhongke Sailifu can better evaluate the degree of aging, and at the same time, through NAD+ detection, NMN can also be found to be unresponsive to the population, providing them with customized solutions
    .


    In the future, the joint laboratory of Zhongke Sailifu will measure aging, help human beings achieve more accurate intervention in aging through comprehensive evaluation of a person's aging degree, improve the current situation of population aging from the social level, and improve the quality of life of
    the elderly.


    It is believed that with more and more powerful combinations, science and technology will show explosive development, and aging will become a disease
    that can be cured.


    References:

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