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PPARs: History and Advances

 Last Update: 2021-01-05
 Source: Internet
 Author: User

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Peroxisome proliferator-activated receptors (PPARs) are members of the steroid hormone receptor superfamily, discovered in1990. To date, three PPAR subtypes have been identified; PPARα, PPAR β/δ, and PPARγ. These receptors share a high degree ofhomology but differ in tissue distribution and ligand specificity. PPARs have been implicated in the etiology as well as treatmentof several important diseases and pathological conditions such as diabetes, inflammation, senescence-related diseases, regulationof fertility, and various types of cancer. Consequently, significant efforts to discover novel PPAR roles and delineate molecularmechanisms involved in their activation and repression as well as develop safer and more effective PPAR modulators, as therapeuticagents to treat a myriad of diseases and conditions, are underway. This volume of
Methods in Molecular Biology
contains details of experimental protocols used in researching these receptors.

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