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    Home > Active Ingredient News > Antitumor Therapy > Practical analysis of mitochondrial energy metabolism pathway in lung cancer

    Practical analysis of mitochondrial energy metabolism pathway in lung cancer

    • Last Update: 2022-03-07
    • Source: Internet
    • Author: User
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    Click to learn about the "star" skillHAPPY NEW YEARSince the phenotype of cell aging is so complex, it is not easy to study it for a while, but this also means that research can be carried out from any angle related to aging
    .

    Let's look at an article on the comprehensive analysis of mitochondrial energy metabolism pathway-related genes in lung cancer
    .

    Comprehensive Analysis of Alteration Landscape and Its Clinical Significance of Mitochondrial Energy Metabolism Pathway-Related Genes in Lung CancersOxid Med Cell Longev, IF=6.
    543 Xiaobian strives to finish it in two sentences: mitochondria are the energy factories of cells, and the mitochondrial energy metabolism pathway is abnormal It is closely related to the occurrence and development of lung cancer (which tumor is not related?)
    .

    The author's series of methods mined genes and clinical biomarkers that affect lung cancer survival, proving that abnormal genes in mitochondrial energy metabolism pathways may be new targets and biomarkers for diagnosis and treatment of lung cancer, abnormal expression and mutation of some genes affect the prognosis of lung cancer
    .

    Forget it, let’s just code words honestly
    .

    Cancer Mitochondrial Ideas Detailed Consultation Understanding Background Metabolic changes in lung cancer affect prognosis and treatment response
    .

    Defects in mitochondrial translation underlie many inborn errors of metabolism and are associated with a variety of diseases, including cancer
    .

    Aberrant mitochondrial pathways and metabolic disturbances can lead to altered gene expression that promotes cancer development, progression, and immune system evasion
    .

    The metastatic cell status of lung adenocarcinoma is associated with specific alterations in mitochondrial function, which opens up new avenues for specific treatment of metastatic lung adenocarcinoma
    .

    Lung cancer exhibits strong mitochondrial glucose oxidation, and the mitochondrial energy metabolism pathway not only affects the occurrence and development of lung cancer, but also is a potential target for lung cancer therapy
    .

    In this study, we analyzed the association of genes in major mitochondrial energy metabolism pathways extracted from the lung cancer TCGA database with lung cancer mutations and clinical characteristics, established a poor prognosis model of lung cancer based on these MMRGs, and further validated the poor prognosis model of this lung cancer.
    accuracy
    .

    These findings will provide promising data for lung cancer patient stratification, precise prognostic assessment, and personalized treatment
    .

    (Implicit) Results MMRG landscape and signaling pathways mediated in lung cancer Mutation status of MMRGs in lung cancer Differential expression of MMRGs in lung cancer and PPI network Survival analysis of differentially expressed MMRGs in lung cancer Immunohistochemical analysis of differentially expressed MMRGs in lung cancer Survival-related differentially expressed MMRGs were validated with different datasets.
    Western Blot of four differentially expressed MMRGs in the construction of a lung cancer machine learning model based on differentially expressed MMRGs.
    Conclusions This study analyzed the expression levels and mutation status of MMRGs in lung cancer and control tissues, and found that Three differentially expressed MMRGs in lung cancer were associated with survival, and aberrant expression and mutation of some genes predicted poor prognosis in lung cancer
    .

    The constructed MMRG feature model has a good ability to distinguish lung cancer and control group, and has important scientific value for the diagnosis and prognosis evaluation of lung cancer
    .

    How do you feel after watching it? There are 10,000 Hamlets in 10,000 readers
    .

    This article was published in December 21, and Hallmarks of Cancer was updated in January 22.
    Although the two are not comparable in most dimensions, they are inextricably linked
    .

    "The energy of the world is conserved", the value of the denominator is also huge, and the precipitation of any argument is an argument, and the editor is no longer nonsense, everyone understands it
    .

    There are no constant hotspots, no expired hotspots, just hotspots and new ones for everyone, and if only one hotspot is eternal, it's alive
    .

    For more hot article ideas, scan the QR code and get on the train to learn more about the new ideas in the new year, and tumor research targeting mitochondria is waiting for you to share
    .

    In other words, contact Shengxin people, bring Fei~
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