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    Home > Active Ingredient News > Infection > Pregnant women need to be alert!

    Pregnant women need to be alert!

    • Last Update: 2021-11-14
    • Source: Internet
    • Author: User
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    ▎Editor of WuXi AppTec's content team Leukemia is the most common type of childhood cancer.
    Although its etiology is not clear at present, some studies speculate that childhood leukemia may be importantly related to the experience of the fetus
    .

    Leukemia-related primary cell clones carry some special gene patterns when the fetus is born.
    At present, there is an infection hypothesis in the field that the immune response caused by a child's infection may activate these primary cancer cells, and ultimately Cause leukemia
    .

    Image source: 123RF Since the fetus is born with these unfavorable genetic factors, studies continue to suggest that the mother's infection during pregnancy is likely to change the immune status in the uterus
    .

    The chromosomal changes caused by some infections are more likely to have a profound impact on the fetus.
    For example, studies have found that pregnant women's infections are related to the incidence of neonatal immune-related diseases.
    Is there a link between leukemia and pregnancy infections? Recently, researchers from the International Childhood Cancer Cohort Coalition (I4C) used data from six countries including Australia, the United States and the United Kingdom to confirm the existence of a link between the two
    .

    According to their paper published in the International Journal of Epidemiology, the team analyzed the data of more than 300,000 children through a cohort study, spanning nearly 60 years from the 1950s
    .

    "The study gives us an opportunity to find ways to prevent childhood cancer," said the lead author of the study, Professor Terry Dwyer
    .

    During a median follow-up of 13.
    6 years, 167 of more than 300,000 children unfortunately developed leukemia, including 129 acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)
    .

    According to the survey report, compared with other mothers, mothers of children with leukemia experienced a higher proportion of common infections during pregnancy
    .

    In the comparison of all infection-related variables, there are 3 kinds of obvious correlations with childhood leukemia, namely: urinary tract infection, cystitis and respiratory tract infection
    .

    For example, a mother’s urinary tract infection during pregnancy can be associated with an increased risk of any type of leukemia in the newborn, including ALL and AML, but this increased risk only occurs in leukemia, and no such link has been observed with other cancer types
    .

    In addition, respiratory infections and other flu-like illness symptoms are also associated with an increased risk of childhood leukemia
    .

    Except for the infections mentioned above, there is no such correlation in other infection types
    .

    Image source: 123RF research speculates that the source of infection and subsequent immune response when pregnant women are infected are direct carcinogenic factors.
    These two factors affect the development of the fetal immune system and even determine the immune response to infection in childhood
    .

    Some viral infections may use specific enzymes to cause genetic mutations in fetal hematopoietic stem cells.
    If other types of infections do not cause chromosomal or immune abnormalities, they will not increase the risk of leukemia in children
    .

    I4C is currently launching another GenV project, which is mainly used to collect medical data of newborns and parents worldwide.
    Their goal is to provide more abundant data for children's disease researchers around the world to help overcome more in the future Childhood diseases
    .

    Reference: [1] Common infections in pregnant mums linked to leukemia risk in children.
    Retrieved Nov 1st, 2021 from https://medicalxpress.
    com/news/2021-10-common-infections-pregnant-mums-linked.
    html[ 2] Jian-Rong He et al, Common maternal infections during pregnancy and childhood leukaemia in the offspring: findings from six international birth cohorts, International Journal of Epidemiology (2021).
    DOI: 10.
    1093/ije/dyab199
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