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Preparation and technical index of isothiazolinone

 Last Update: 2022-01-04
 Source: Internet
 Author: User

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Isothiazolinone

[Alias] The first class of pharmaceuticals developed and researched by Rohm & Haas in the United States, and commercialized production.

[Structural formula]

[Physical and chemical properties] White solid, soluble in water, lower alcohols, ethylene glycol and polar organic solvents.

[Preparation method] The synthetic method of isothiazolinone was first proposed by Goerdeler and Mittler, and then Rohm&Haas in the United States conducted a comprehensive research on this type of compound, and finally formed two more commonly used synthetic methods

(1) It is prepared by reacting dithiodiamide with a halogenating agent in an inert solvent.

The first step, the amidation process:

The second step is to neutralize after cyclization:

(2) The method for preparing isothiazolinone with mercaptoamide as raw material, the reaction formula is as follows:

[Technical index]HG/T3657-1999

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