echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Drugs Articles > Problems and solutions in the production process of tablet press

    Problems and solutions in the production process of tablet press

    • Last Update: 2018-06-27
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    When the tablet is pushed out of the mold hole, the phenomenon of falling off is called crack Sometimes the middle of the tablet splits into two pieces, but this rarely happens In the process of tablet pressing, the reason for the split is that the air does not escape when the fine powder in the particle is compressed too much, the compression speed is too fast, the gap between the punch and the die hole is relatively small, the air is not pressed out, the air is closed in the tablet, and the air will expand after the pressure, leading to the split phenomenon According to the above, the fine powder in the particle should be removed so that the air in the tablet can escape When the pressure is high, we can reduce the pressure properly to prevent it from cracking If the particle is too dry, it will cause cracking We should adjust the water content to prevent cracking Due to the improper compression behavior of particles, the strong elasticity of particles will produce cracks in the process of compression After compression, the elastic recovery rate of tablets is relatively high, which is also caused by the uneven pressure during compression When the single tablet press presses the tablet, it's unilateral pressure When the rotary tablet press presses the tablet, it's up and down together The elastic recovery rate is related to the pressure The pressure time on the upper surface of the tablet is short, so you can first crack from the top Knowing this, you can guide how to prevent the crack For example, you can adjust the prescription design, increase the plasticity of raw materials and auxiliary materials, Particle compression molding time improved, and so on Reducing the compression pressure will also prevent the crack, because the small pressure will reduce the elastic recovery rate, and the appropriate moisture content in the particles will increase the plasticity of the particles to improve the pressure distribution and prevent the crack It is also possible to add lubricant or flux properly There are other reasons for the split, such as mold hole deformation, machine wear will also lead to tablet split.
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.