Problems encountered in amino acid shrinking.

: Recently I have done a series of
amino acids
shrinkage reaction, but there is a specific set of arbonds and amino is not reactive, try a lot of methods, such as EDCI, CDI, PyBOP, etc., due to nircolasine
compound
there is an unpentanced methylene ring, has also tried to use dichloroacetylamide as acetyl chloride, as if not, do not know whether you have a better high trick, or whether to use some kind of protective base to protect the methylene ring feasible, please teach!
To participate in the reaction of the amine is a fat family beramine, but bit resistance is a bit large, but that amine is not unable to shrink, with it and other acid reaction without mimi ring, very good, with EDCI can be.
: Have you ever heard of
peptide
synthesis, the amino acid of the unpentant methane ring has an HIS histamine, in the
peptide synthesis
, you can use a variety of protective groups to protect this mide N, you may be useful boc and Trt (triamcinolone), if you think this method is feasible, need specific literature, I'll look at it for you.
, using the DCC/NHS method, and is suitable for the opposite of water, because the amino acids themselves are very water-soluble..