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13.
(1) Liquid chromatography conditions
Chromatographic column: Inertsil ODS-3, 5 um, 150mm×2.
Table 13-6 Mobile phase and gradient
(2) Mass spectrometry conditions
Ion source: electrospray ion source; scanning method: positive ion scan; detection method: multiple reaction detection (MRM); electrospray voltage (IS): 5000V; atomizing gas pressure (CAS1): 482.
Table 13-7 Mass spectrometric parameters of 8 tranquilizers
(3) Qualitative determination
Choose one parent ion and two or more product ions for each tested component.
(4) Quantitative determination
Inject samples with mixed standard solutions separately, draw the standard working curve with the peak area as the ordinate and the concentration of the working solution as the abscissa, and use the standard working curve to quantify the sample, the tranquilizer and its metabolites and β-blocking in the sample solution The response value of the agent should be within the linear range determined by the instrument
Table 13-8 Reference retention time of 8 tranquilizers
Related links: Pretreatment of samples for determination of 8 tranquilizer residues in pig kidney and muscle tissue, milk and milk powder