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    Home > Active Ingredient News > Drugs Articles > Process effect of spray dryer

    Process effect of spray dryer

    • Last Update: 2018-12-03
    • Source: Internet
    • Author: User
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    The spray drier material is atomized by atomizer, dispersed into fine droplets into the drying chamber At the same time, the heated gas is sent to the heater through the blower to heat up, and then enters the drying chamber The material liquid droplets and hot gas are fully mixed and contacted in the drying chamber The droplets evaporate into gas and the material is dried into fine particles The mixed gas-solid two-phase is sucked into the cyclone separator by the induced draft fan for separation, the solid material settles to the bottom collector, and the gas phase is led to the dust filter to catch the escaped material After the filtered gas phase is condensed by the condenser, the carried solvent becomes liquid, which can be collected and applied The carrier gas is dried and recycled in the system Solid preparation requires a wide variety of solid preparations and different processing requirements In the process of designing and manufacturing spray dryer, Zui aims at making different designs for different varieties so as to meet the Zui optimum condition of equipment and process Cleaning requires that the main process of API production should be carried out in a clean environment of one hundred thousand levels Spray drying is an important process of quality control The contact parts of spray dryer should be made of stainless steel 316L stainless steel is suitable for Zui with strong corrosiveness Dry chamber, cyclone separator, filter and other parts directly contacting with materials shall have smooth inner wall, no dead angle, easy to disassemble and clean Spray dryer often has large system, so it can not be put in the clean area as a whole It often only puts part of the collected material in the clean area, which requires that the system has good airtight performance to prevent the external pollution system Avoiding sticky wall phenomenon is a serious problem that hinders the normal operation of spray dryer The spray drying process of solid preparations (especially Chinese Medicine) is particularly obvious Material sticking to the wall is not only not conducive to the collection operation, but also with the extension of time, sensitive sticking materials will deteriorate into unqualified materials From the point of view of technology, the solutions include choosing suitable solvents, adding auxiliary materials and changing process parameters However, there is not much room for these methods to be adjusted Therefore, it is necessary to seek fundamental solutions from the perspective of equipment Experts at home and abroad have studied the problems of wall sticking and caking in the drying process, and they think that the main reason of wall sticking is the wall temperature.
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