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2-aminopyridine (2-aminopyridine) is also known as a-aminopyridine, a-aminoazabenzene, and a-pyridinamine.
The molecular formula is C 5 H 6 N 2 , the molecular weight is 94.
12, and the structural formula is
1.
Product performance
Colorless flake or granular crystals, bitter taste; melting point 58°C, boiling point 204°C, 104~106°C (2.
67kPa), flash point 110°C; soluble in ethanol , benzene, ether and water, sublimable; has anesthetic effect; Poisonous
.
2.
Production principle
Using toluene as a solvent, pyridine and sodium amide undergo a nucleophilic substitution reaction, and 2-aminopyridine is obtained by hydrolysis
.
3.
Process flow
4.
Technical formula (kg/t)
5.
Main equipment
Toluene drying kettle, reaction kettle, storage tank, oil-water separator, extraction tank, desolventizing kettle
.
6.
Production process
600kg of toluene was added to a dry stainless steel reactor to heat, and the toluene was distilled out until the distillate was clear
.
After cooling to below 35°C, add 185kg of sodium amide.
7.
Product Standard
8.
Product use
Used in the pharmaceutical industry, dye synthesis industry and organic synthesis; also used as a reagent for testing ladders, bismuth, cobalt, copper, gold and zinc
.
9.
Safety measures
(1) The raw material sodium amide is a first-class flammable solid, so it should avoid contact with air, water and heat sources to avoid explosion and fire
.
The raw material pyridine is poisonous, and toluene is poisonous and flammable
(2) The product is more toxic than pyridine, easily absorbed by the skin, and can be fatal in severe cases.
It is irritating to the skin and mucous membranes.
The LD 50 value for rats is 200mg/kg
.
The mouse LD 50 value is 50 mg/kg
(3) Store in a cool, dry place sealed and protected from light
.
Store and transport in accordance with toxic chemicals regulations
Related links: Production principle and process flow of semicarbazide hydrochloride