-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Ethyl p-aminobenzoate (ethyl-p-aminobenzoate), also known as ethyl 4-aminobenzoate, benzocaine (benzocaine), molecular formula is C9H11NO2, molecular weight is 165.
2, structural formula is
1.
Product performance
Colorless rhomboid crystals; melting point 88～90℃, boiling point 183～184℃(14×133.
2Pa); stable in the air, odorless, bitter taste; slightly soluble in water, soluble in ethanol , chloroform , ether , olives Oil is also soluble in dilute acid; it is alkaline; it turns yellow when exposed to light
.
2.
Production principle
Under the catalysis of sulfuric acid, p-nitrobenzoic acid is esterified with ethanol, and the obtained ethyl p-nitrobenzoate is reduced with iron powder to obtain a finished product
.
3.
Process flow
4.
Technical formula (kg/t)
5.
Main equipment
Enamel reaction kettle, reduction kettle, vacuum drying oven, centrifuge, extraction kettle, storage tank
.
6.
Production process
Add 192kg of ethanol into the enamel esterification reactor, add 66.
6kg of concentrated sulfuric acid while stirring, and control the temperature to be less than 50°C
.
When the kettle is cooled to 30°C, add 95.
Add 500kg of water, 45kg of sodium chloride , 70kg of iron powder and 10kg of hydrochloric acid to the enamel reduction reaction gold
.
Stir and heat the temperature to 90°C, and activate the reaction for 1h
.
When the temperature is lowered to 85℃, add 100kg of ethyl p-nitrobenzoate into the kettle, add 20kg of iron powder, and keep the temperature at 90～95℃ and stir for 4～5h
7.
Laboratory preparation method (reagent grade preparation method)
A solution made of 39 g of ethyl p-nitrobenzoate and 200 mL of 95% ethanol was put into the catalytic reduction reactor, and 0.
4 g of platinum oxide catalyst was added
.
Feed in hydrogen until 6 mol of hydrogen is absorbed
8.
Product Standard
9.
Quality inspection
Content determination: accurately weigh 0.
35g sample and titrate with 0.
1mol/L sodium nitrite .
Each millimole of sodium nitrite is equivalent to 165.
29mg ethyl p-aminobenzoate
.
10.
Product use
This product is a local anesthetic used for relieving itching and pain on wounds, ulcers and hemorrhoids, with a concentration of 5%-20%
.
It is also used as an intermediate in drug synthesis and organic synthesis
.
11.
Safety measures
(1) This product is less irritating and toxic, but the production equipment should be sealed, and the operator should wear labor protection equipment
.
(2) Store in airtight and dark place
.
Related links: Process flow and product use of ethyl propionate
