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    Home > Chemicals Industry > Chemical Technology > Product uses and safety measures of 2-chloro-4-nitroaniline

    Product uses and safety measures of 2-chloro-4-nitroaniline

    • Last Update: 2021-08-28
    • Source: Internet
    • Author: User
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    2-chloro-4-nitroaniline (2-chloro-4-nitroaniline) is also known as o-chloro- p -nitroaniline, 4-amino-3-chloronitrobenzene (4-amino-3-chloronitrobenzene), the molecular formula is C 6 H 5 CIN 2 O 2 , the molecular weight is 172.
    58, and the structural formula is

    1.
    Product performance

    Yellow needle-like crystals, melting point 107~109℃; soluble in ethanol , ether , carbon disulfide and benzene, slightly soluble in water and 50% acid, insoluble in crude gasoline; toxic
    .

    2.
    Production principle

    After p-nitroaniline is salted with hydrochloric acid, it is chlorinated with sodium hypochlorite to obtain the product
    .

    3.
    Process flow

    4.
    Technical formula (kg/t)

    5.
    Main equipment

    Reaction pot, filter press, storage tank, dryer
    .

    6.
    Production process

    Add 450L of water, 1120kg of 30% hydrochloric acid to the reaction pot, increase the temperature to 50°C, add 185.
    6kg of p-nitroaniline, and stir for 20min to dissolve

    .
    Add ice to cool down to about -2°C, slowly add 1120kg of 10% sodium hypochlorite solution from below the liquid surface, use starch potassium iodide test paper to test at any time during the reaction, it should be slightly blue

    .
    After about 4h, the feeding is finished, keep 0~2℃ and continue to stir and react for 2h.
    Check with
    potassium iodide starch test paper and still show light blue unchanged, which is the end point
    .
    Add water to adjust the volume to 6000L, let it settle for precipitation, and remove the upper layer of waste acid

    .
    Add water to a total volume of 6000L

    .
    After stirring, let it stand, remove the waste acid layer, press filter, rinse with clean water, and dry, and the finished product is about 200kg

    .

    7.
    Product Standard

    8.
    Quality inspection

    Assay: Accurately weigh about 2.
    5g sample, place it in a 400mL clean drying cup, add 30mL hydrochloric acid and 100mL distilled water, heat and dissolve on an electric stove, add distilled water to dilute to a total of 300mL

    .
    This solution is cooled to 0 ~ 10 ℃

    .
    Then insert the tip of the burette into the solution, and under constant stirring, add 0.
    5mol/L
    sodium nitrite standard solution (95% of the required amount) at once
    .
    Then take the tip of the burette out of the liquid surface, rinse the tip of the burette with distilled water, add 0.
    5mo/L sodium nitrite standard solution drop by drop until the solution makes the potassium iodide-starch test paper slightly blue, and keep it for 5 minutes without fading, that is the end point

    .
    Do a blank experiment at the same time

    .

    In the formula: c——molar concentration of sodium nitrite standard solution, mol/L;

    V——The volume of sodium nitrite standard solution consumed by the sample, mL;

    V 1 ——The volume of sodium nitrite standard solution consumed in the blank experiment, mL;

    G——The mass of the sample, g
    .

    9.
    Product use

    Used as dyes, pigments and pharmaceutical intermediates, such as the synthesis of Disperse Red B, Silver Bead R, and Schistosomiasis-67 paste
    .

    10.
    Security measures

    (1) The raw material is highly toxic to nitroaniline, and the maximum allowable concentration in the air is 0.
    0001%

    .
    The product is an organic drug

    .
    The chlorination equipment should be sealed, the operators should wear labor protection equipment, and the workshop should be well ventilated

    .

    (2) The products are packed in iron drums or plastic bags and stored in a cool, dry place
    .
    Store and transport in accordance with toxic chemicals regulations

    .

     

     

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