-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
M-nitrocinnamic acid (m-nitrocinnamic acid) is also known as 3-nitrocinnamic acid, 3-(3-nitrophenyl)acrylic acid [3-(3-nitropheny/l)acrylic acid], the molecular formula is C 9 H 7 NO 4 , the molecular weight is 193.
16, and the structural formula is
1.
Product performance
There are two isomers of cis and trans.
The trans is yellow needle-like crystals; the melting point is 200～202℃; it is soluble in ethanol and hot benzene, slightly soluble in water, and soluble in alkaline aqueous solution; it can be sublimated and slightly distilled.
Decomposition; cis melting point is 158℃, unstable
.
2.
Production principle
Benzaldehyde is nitrated to obtain m-nitrobenzaldehyde, which then undergoes condensation reaction with acetic anhydride in the presence of sodium acetate
.
3.
Process flow
4.
Technical formula (kg/t)
5.
Main equipment
Nitrification reactor, filter, storage tank, condensation kettle, oven
.
6.
Production process
Add 2660kg of concentrated sulfuric acid into the dry nitration reactor, add 264kg of sodium nitrate under stirring , and increase the temperature to 75°C to dissolve the sodium nitrate
.
Cool down to 5°C, add 200kg benzaldehyde dropwise, and keep it at 5-8°C for 1h
7.
Laboratory preparation method
In a round-bottomed flask equipped with a reflux condenser, add 100 g of m-nitrobenzaldehyde, 80 g of freshly melted sodium acetate and 140 g of acetic anhydride, and heat them in an oil bath at 180°C for 13 hours
.
Cool slightly, pour it into 500 mL of water to crystallize, filter by suction, dissolve in a solution of 40 mL of ammonia and 400 mL of water after washing, and filter
8.
Product Standard
9.
Quality inspection
Assay: acid-base titration method, KOH/ethanol solution titration, phenolphthalein as indicator
.
In the formula: c——The concentration of potassium hydroxide ethanol solution, mol/L;
V—— The volume of potassium hydroxide ethanol solution consumed by the sample , mL;
G—The mass of the sample, g
.
10.
Product use
Used as organic synthesis and pharmaceutical intermediates
.
11.
Safety measures
(1) The raw material benzaldehyde, the intermediate meta-nitrobenzaldehyde and the product are all poisonous.
Concentrated sulfuric acid, acetic anhydride and other corrosive materials are also used in the production.
The equipment should be sealed, the workshop should be well ventilated, and the operators should wear labor protection equipment
.
(2) Stored in a cool, dry place in a sealed package and protected from light
.
Related links: Production process and product standards of m-aminobenzoic acid
