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    Home > Chemicals Industry > Chemical Technology > Production process and quality inspection of p-nitroacetophenone

    Production process and quality inspection of p-nitroacetophenone

    • Last Update: 2021-08-11
    • Source: Internet
    • Author: User
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    6.
    Production process

    In the mixing tank, 180kg of concentrated nitric acid and 380kg of concentrated sulfuric acid are mixed to form a mixed acid for later use
    .


    Add 300kg of ethylbenzene into the enamel reactor, and when the temperature is raised to 32°C±2°C, start to slowly add the prepared mixed acid dropwise


    The oxidation reaction is carried out in an autoclave that can withstand 1.
    0MPa
    .


    First, 600 kg of p-nitroethylbenzene prepared above was put into a 1000 L autoclave, and then 50 g of cobalt stearate and 60 g of manganese acetate were added as catalysts


    Stop air flow and relieve pressure
    .


    When cooled to 80°C, the reaction materials were transferred to the neutralization kettle, and sodium carbonate was added to neutralize the pH to 7-8


    7.
    Laboratory preparation method

    Put 200mL of water, 50g of magnesium nitrate hexahydrate and 15.
    1g of p-nitroethylbenzene in a three-necked flask, stir and heat to 60°C
    .


    Add 25g of finely ground potassium permanganate in four times, and add the next batch when the purple color of the solution disappears


    8.
    Product Standard

    9.


    Quality inspection

    Assay: accurately weigh 1.
    2g of the sample, dissolve it with ethanol, and dilute to 100mL
    .


    Weigh another 1.


    Take 100mL of 2,4-dinitrophenylhydrazine solution in a 600mL beaker, and then take 100mL of sample solution and add
    .


    After stirring for 5-10 minutes, add 400 mL of water, keep it in an oven at 80°C for 3 minutes, filter in a constant-volume pore funnel, and wash with 20 mL of 1mo/L sulfuric acid


    In the formula: W 1 —— sample mass, g;

    W 2 ——product quality, g
    .

    Gas chromatography can also be used to determine the content
    .

    10.


    Product use

    It is used as an intermediate for organic synthesis and pharmaceutical synthesis (such as synmycin and chloramphenicol); it is also used for the synthesis of pesticides, dyes and perfumes
    .

    11.
    Safety measures

    (1) This product is toxic, and mixed acid is used in production
    .


    The equipment must be closed, and the workshop must be well ventilated


    (2) Packed in iron drum lined with plastic bag, stored in a cool, dry, ventilated place, protected from heat, moisture, and sunlight, and sealed
    .

    Related links: Production principle and technical formula of p-nitroacetophenone

     

     

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