Professional science popularization! How did the self novel coronavirus pneumonia do?

Novel coronavirus pneumonia is actually a self limited disease in February 10th Zhang Dingyu, President of Wuhan golden Yin Tan Hospital, said that the cure rate is still high and there is no need to panic too much What novel coronavirus pneumonia Wang Fusheng resolved in China on February 21st is what is self limiting disease, but emphasizes that self limited disease does not mean that no treatment is needed What is self limiting disease? What is novel coronavirus pneumonia as a self limiting disease? Since self limited diseases can heal themselves, why do they need treatment? How to judge whether the patient is cured by medication or recovered by autoimmunity? After the occurrence and development of self limited diseases to a certain extent, self-regulation of the body can control the development of the disease and gradually recover The most common self limiting disease is "common cold" (mainly caused by rhinovirus and Coronavirus) For the treatment of the common cold, there is a saying that "science": "cold, take medicine, 7 days good; do not take medicine, a week good" This is a precise description of self limited diseases Generally speaking, in the absence of other serious complications, it can wait for its own recovery only if it is treated symptomatically or not Some viral infections and autoimmune diseases are common self limiting diseases, such as varicella, subacute thyroiditis, rotavirus enteritis and so on Let's see novel coronavirus pneumonia The first stage (incubation period): the new crown virus (SARS-CoV-2) enters the body, especially the lungs, and quietly copies without clinical symptoms; the second stage (progress stage): the human body's immune system recognizes the intruder, alarms the alarm, deploys the troops, sends white blood cells, lymphocytes, macrophages and other fighters to eliminate the new crown virus; third Stage (recovery stage): the immune system of the human body defeats the virus, clears the virus in the human body, and the patient recovers For most novel coronavirus pneumonia patients, the plot is so simple If we need to add a picture, it is that the body temperature is increased during the fighting process, which is conducive to killing the virus So we have a fever There are too many viruses and corpses, which need to be removed from the body, so we cough.. Some people doubt that there is a lack of medicine in the fangcang hospital In fact, for the patients with mild illness, they need more care and comfort (placebo may be a "good medicine" at this time) The plot of severe patients is more tortuous, some of them are accompanied by cardiovascular disease, diabetes, etc., which cause the immune cells to attack the cells in the lesion site; some of them are caused by the excessive reaction of the immune system, which leads to the cytokine storm, a large number of immune cells carry out indiscriminate attack on the lung cells, resulting in breathing difficulties and shock, which need to be treated by oxygen supply, or The treatment of the disease helps the patient to get through the difficulties, but the task of killing the virus, in the absence of specific drugs at present, can only rely on their own immunity So what are the effects of these drugs, or do they work? At present, it is mainly symptomatic treatment and life support treatment Even if fever and cough are the normal body reactions to kill the virus, but if the reactions are excessive, they need to be controlled so as not to hurt the innocent This kind of drugs are ready-made and need not be re studied What we really need to study is the drugs that directly kill the virus, namely the so-called special drugs Radcivir, chloroquine, Kriging, abidol, etc are among the candidate drugs The author said in the article "who has the final say in the effectiveness of drugs?" Reed's clinical trial of super ox "random, double-blind, controlled clinical trials are the international standards to verify whether a drug is effective This gold standard is like a mirror or monkey king's eyes, which can distinguish whether a drug is effective and return a "magic drug" to its original form This is especially true for drugs used for self limiting diseases If there is no control, people who are confused can easily succeed The novel coronavirus novel coronavirus, Ke Lizhi, and ritonavir (trade name: Ke Lizhi) are the first to be tried in the treatment of new coronavirus pneumonia, which has been highly anticipated and written into a new diagnostic and therapeutic plan for coronavirus pneumonia However, according to the latest research published recently by the public health clinical center of the city of Shanghai: Based on the standard treatment of 134 cases diagnosed as pneumonia The results showed that there was no significant difference between the three groups The control group who did not take antiviral drugs also had a better negative rate of pathogenic nucleic acid (7 days, the ratio of positive to negative reached 77%) The negative time of viral nucleic acid in patients is shown in the figure below, that is to say, with or without drugs, there is basically no difference, and the virus can disappear as well It can be seen that without the verification of the control test, even if the guide is written, it may not be reliable Although the novel coronavirus pneumonia is a self limiting disease, it is also an infectious disease, and may cause serious complications and even life-threatening Therefore, it is still necessary to observe or treat in the hospital At the same time, because he is a self limiting disease, although we haven't found a specific drug, even if the clinical trials of potential specific drugs such as radcivir and chloroquine fail in the future, we are not without drug effectiveness, because the human body's own immunity is our most powerful weapon Listen to the white statement: this point of view only represents the author, not the position of yaozhi.com, welcome to exchange and supplement in the message area; if you need to reprint, please be sure to indicate the author and source of the article.