Professor Bai Zhengyu and Professor Yang Lin of Henan Normal University "ACS AMI": Used for the...

With the development of biomedical technology, implantable biofuel cells have great application requirements as the power source of implantable medical detection devices such as cardiac pacemakers
.

Glucose biofuel cell (GBFC) is the best choice for implantable biofuel cells, because the fuel (oxygen and glucose) of the anode and cathode of

Recently, the team of Professor Bai Zhengyu and Yang Lin from the School of Chemistry and Chemical Engineering of Henan Normal University published a titled " Construction of a Cascade Catalyst of Nanocoupled Living Red Blood Cells for Implantable Biofuel Cell " on ACS Appl ied Mater ials & Interfaces (IF: 8.

758) Academic papers .
This paper describes the construction of a nano-modified living cell catalyst RBCs@NPDA by coupling nano-polydopamine (NPDA) with red blood cells (RBCs) .

Characterization of RBCs@NPDA

The SEM test image shows that the surface of RBCs@NPDA is significantly different from that of natural RBCs .

The surface of natural RBCs is smooth (Figure 1d and e ), while the surface of RBCs@NPDA is relatively rough due to the coating of NPDA nanoparticles (Figure 1 a and b ); in addition

Figure 1 (a) and (b) are the overall and partial enlarged SEM images of RBCs@NPDA , respectively ; (d) and (e) are the overall and partial enlarged SEM images of natural RBCs , respectively ; (c) and (f) are respectively RBCs @ NPDA pureRBCs of FTIR , the UV-Vis spectra of FIG .

Biochemical properties of RBCs@NPDA

In order to test the integrity and biocompatibility of the cell
membrane of RBCs@NPDA , the osmotic fragility of the cells and the hemolysis in their own blood were tested .

Figures 2a and b show that the NPDA modified layer on the cell surface has good biocompatibility and has almost no effect on the permeability of RBCs .
The cell membrane of

FIG 2 (a) and (b) are RBCs @ NPDA and natural RBCs osmotic fragility curves and hemolysis test curve; (C) RBCs @ NPDA and natural RBCs in 0.

3 mM H ₂ O ₂ in PBS (.
1 × ) solution of The UV-Vis spectrum; (d) Test chart of oxygen production in a PBS (1 × ) solution containing 0.
3 mM H ₂ O ₂ with and without NPDA nanoparticles .

Electrochemical performance of RBCs@NPDA

Figure 3 is a series of electrochemical test diagrams of RBCs@NPDA as a cathode catalyst.

It can be seen that the NPDA modified layer of RBCs@NPDA promotes the electron transfer between RBCs and the electrode, and couples the ability of NPDA to catalyze the decomposition of H ₂ O ₂ and RBCs.
The characteristics of catalytic oxygen reduction, thereby showing more stable electrocatalytic reduction performance for the  O ₂ -H ₂ O ₂ cascade reaction

FIG.

(A) 3 under atmospheric conditions, different concentrations of H ₂ O ₂ solution, the RBCs @ NPDA the CV curves; (B) 0.
3 mM H ₂ O ₂ solution, the RBCs @ NPDA different scan rates CVs ; (C) Peak current scan speed diagram; (D) RBCs @ NPDA of It curves; (E) RBCs @ NPDA the EIS FIG.
; (F) to GOx and RBCs @ NPDA as anode and cathode catalysts, assembled into a filmless GBFC battery Test chart

Related Links

https://doi.
org/10.
1021/acsami.
1c01479