Professor Chen Jie, Jiangnan University: Changes in the metabolism of SD rats caused by harmful Merad reaction products and high-fat diets

Highlights:
- These harmful Maillard reaction products (MRPs) have toxic effects on the liver, kidneys and nervous system.
metabolism is affected by acrylamide.
accumulation of acrylamide, NƐ-(carboxymethyl) lysine, CML) and harmane significantly alters metabolites and disrupts metabolic pathways.
interactions between 1.3 billion and MRPs and exhibit toxic effects at metabolic levels.
Summary
Wei Quan, Maomao Zeng, and Jie Chen of Jiangnan University's National Key Laboratory for Food Science and Technology feed rats with high-fat feed and use acrylamide (21 mg/kg BW), halmantine (7 mg/kg BW),
N
Ɛ
-(carboxymethyl) lysine (carboxymethyl), CML; 10mg/kg BW) treatment or the joint accumulation of these three chemicals to study the effects of harmful Merad reaction products (Mailboxymethyl, MRPs) produced by potato thermal processing. After 6 weeks of feeding, damage to the liver, kidneys, fibula and nervous system was confirmed through serum biophysical and tissue pathology tests. Serum metabolomic analysis was performed using gas chromatography time-of-flight mass spectrometry( GC-TOF-MS). Metabolites detected by GC-TOF-MS are treated with chemical metrology techniques, the results are evaluated with a
t
test (
p
<0.05) and combined with variable projection importance analysis (variable importance in projection, VIP) values (>1.5). Compared to the control group, there were significant changes (increases or decreases) in 13 metabolites. These metabolites include glucose, tyrosine, 5-hydroxytryptophan, erythromytose-4-sodium phosphate, quinine, 2-ketonebutyric acid, tyrosine, 3-hydroxy-3-methylline diacid, deamytamate,
L
-cysteine, nucleic acid, cysteine, and tryptophan. Among them, cysteine and tryptophan were the metabolites unique to the accumulation of these three test chemicals in the subject rats. This study shows that these harmful MRPs have toxic effects on the liver, kidneys and nervous system through different metabolic pathways. In addition, the co-accumulation of these harmful MRPs causes different toxic effects and changes in a variety of metabolites. These changes can lead to these harmful MRPs interactions and exhibit toxic effects at metabolic levels.
Jie
Professor
Chen Jie, professor and doctoral tutor of Jiangnan University's School of Food, and executive deputy director of Jiangnan University's National Center for Functional Food Engineering Technology Research. He has served as Director of jiangnan University's Center of Excellence in Teaching Evaluation and Teachers, secretary-general and chief of staff of Jiangnan University's Academic Committee, deputy director of the National Key Laboratory for Food Science and Technology, and director of Jiangnan University's Testing Center. Dr. 2001.1 graduated from the School of Food of Jiangnan University and conducted postdoctoral research in the Department of Agriculture, Kyoto University, Japan, from 2003 to 2005. He was promoted to professor in 2006. The research focuses on food science, focusing on the structure and function of protein in food, the structural changes of protein in food processing process and its effect on food quality, especially on vegetarian meat, meat products, soy products and dairy products. He has presided over more than 10 national and ministeral provincial projects, including the "973" program, 4 national natural science foundations, the "12th Five-Year Plan" national support plan and the "12th Five-Year Plan" instrument special projects, and participated in research work on more than 10 national and provincial projects, including the 13th Five-Year Plan, the "973" project, major projects in Jiangsu Province, and more than 10 national and provincial projects. With the United States group, Henan Jinjing Biological, Jingjiang Pisces meat, Shandong Huifa, Xiamen Yinxiang and other long-term cooperation. Research published more than 200 papers (including more than 100 SCI papers), licensed invention patents more than 20. Is the 2018 Young Workers Federation of Science and Technology Progress Second Prize (ranked first), the 2011 Ministry of Education Science and Technology Progress First Prize (ranked first), the 2010 Jiangsu Province Six Peak Talent Program, the 2007 Ministry of Education New Century Talent Program, 2011 and 2007 Jiangsu Province 333 projects The Youth Science and Technology Leader Program, the first prize for scientific and technological progress of the Ministry of Education in 2006 (ranked third), the 2004 Ho Yingdong Education Foundation Youth Teacher Award and other provincial and ministerial award winners, and has been awarded the 2016 Weijiang Scholars Lecture Professor, 2007 Wuxi City, the top ten outstanding young people and other titles.
author's profile comes from Jiangnan University's official website
(the article "Metabolic changes from exposure to harmful Maillard reaction products and high-fat diet on Sprague-Dawley rats" is published online in Food Research International. ）