Professor Chen Jinjun's team of Southern Hospital has published two new results in the Journal of Hepatology, an international authoritative academic journal

Recently, the research results of Professor Chen Jinjun's team in the field of end-stage liver disease and portal hypertension non-invasive diagnosis of end-stage liver disease and portal hypertension in the international authoritative academic journal have been published
in the Journal of Hepatology.

Microbial characteristics in circulating patients with acute decompensation of liver cirrhosis were discovered based on pathogenic metagenomic next-generation sequencing (mNGS).

On October 26, Professor Chen Jinjun of the Liver Disease Center of Southern Hospital and Professor Rajiv Jalan of University College London collaborated to publish an online report entitled "Prognostic and therapeutic significance of microbial cell-free DNA in plasma of people with" in the Journal of Hepatology, a top journal in the field of international hepatology acutely decompensated cirrhosis", with Hong Changze, a postdoctoral fellow in infectious diseases and 2020 master's student, as the co-first author, Professor Chen Jinjun and Professor Rajiv Jalan as the co-corresponding authors of the paper, and Nanfang Hospital of Southern Medical University as the first signature of the paper
.

Cirrhosis-associated immune dysfunction is associated with progression of acute decompensation and increases the risk
of death in patients with cirrhosis.
Current studies have focused on bacterial and fungal infections, while the role of non-hepatotropic viral infections in the progression of acute decompensation in cirrhosis is unclear
.
The study used the pathogen macromNGS to detect microbial genomic fragments in the plasma of patients with decompensated cirrhosis, and the study found for the first time that patients with decompensated cirrhosis have characteristics of non-hepatotropic virus infection, which are similar
to those of patients with sepsis and hematological tumors.
CMV is the most common nonhepatotropic virus, and this nonhepatotropic viral feature is associated with
response to antimicrobial therapy, progression of chronic acute liver failure, and 90-day mortality.
The result of this research is the first paper
in the field.

Compared to other models, the Baveno VII algorithm is most effective in excluding high-risk varicose veins in patients with hepatitis B cirrhosis

On November 8, Professor Chen Jinjun and Dr.
Wang Haiyu of the Liver Disease Center of Southern Hospital published the title "Baveno VII algorithm outperformed other models in ruling out high-risk varices in individuals with HBV-related cirrhosis" online in the Journal of Hepatology Research papers
.
Zhang Xiaofeng, chief resident physician of the Department of Hepatology of Zengcheng Campus, Song Health, a 2022 doctoral student in the Department of Infectious Diseases, and Zhang Yuanjian, an eight-year graduate student in 2015, are co-first authors, and the Southern Hospital of Southern Medical University is the first signature of the paper
.

The study is based on FibroScan® clinical data, which verifies the excellent diagnostic efficacy of spleen hardness measurement in excluding high-risk gastroesophageal varices in patients with HBV-related cirrhosis under the Baveno VII criteria, and the Baveno VII algorithm using FibroScan's® novel spleen hardness measurement can safely exempt more gastroscopy screening
than other models 。 The research results follow the publication of "Baveno VI criteria and spleen stiffness measurement rule out high-risk varices in virally suppressed HBV-related cirrhosis" published by Professor Jinjun Chen's team in the Journal of Hepatology in 2021.
Another important research result
in the non-invasive diagnosis of portal hypertension.

In recent years, under the leadership of Director Hou Jinlin, the Department of Infectious Diseases has paid attention to the infection of end-stage liver disease and the non-invasive diagnosis of
portal hypertension.
In the direction of end-stage liver disease, Professor Chen Jinjun of the Department of Infectious Diseases led one major special project of infectious diseases in the 13th Five-Year Plan of the Ministry of Science and Technology, undertook one key research and development sub-project, and obtained 3 projects funded by the National Natural Science Foundation of China
.
The above research results were completed under the funding of the 13th Five-Year Infectious Major Project of the Ministry of Science and Technology and the National Key R&D Program, which is a landmark achievement
of the infectious medicine team in the field of end-stage liver disease and non-invasive diagnosis of portal hypertension.