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    Home > Medical News > Latest Medical News > Professor Han Jingyan, Medical Department of Peking University: Combining Chinese and Western medicine to build a healthy levee.

    Professor Han Jingyan, Medical Department of Peking University: Combining Chinese and Western medicine to build a healthy levee.

    • Last Update: 2020-07-29
    • Source: Internet
    • Author: User
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    Introduction: Professor Han admitted that scientific research should not stop at "scientific research", can not only "scientific research."!---- He has been studying the pathological basis and biological mechanisms of the difficult-to-treat links of major diseases, and explores the core theory of Traditional Chinese Medicine and the scientific connotation of compound Chinese medicine from the perspective of the combination of Chinese and Western medicineHe published more than 80 research papers and reviews of Chinese and Western medicine, such as hemorrhoids and live haemorrhagic seis, in internationally renowned journals, and published a monograph on ischemic reperfusion injury and Chinese medicineAfter a long period of research, his team partially revealed the scientific connotations of air-fake blood and gas-replenished live blood, gas-hydration blood and gas-based live blood, hot and cold blood, cold clotting blood and warm blood, traumatic blood and live bloodIn the field of gas-false blood and gas-replenishing live blood, this paper expounds the effect and mechanism of improving the heart muscle fertility caused by the lack of capacity of the compound Chinese medicine preparation, the ginseng gas droplet, and its fibrosis, and the improvement effect and mechanism of myocardial fertilization caused by the increase of pre-cardiac resistance caused by excessive energy consumptionHe is Professor Han Jingyan, Director of the Department of Chinese and Western Medicine, Department of Chinese and Western Medicine, Institute of Chinese and Western Medicine, and Director of the Department of Chinese and Western Medicine Combined Research, School of Basic MedicineRecently, Biodiscovery had the honor of interviewing Professor Han and listening to his story of combining Chinese and Western medicineProfessor Han devoted himself to the study of the scientific connotation of the theory of hemorrhoids and activated hemorrhoids, to study the mechanism of compound Chinese medicine to improve microcirculation disorders, to train graduate students and young scholars, and also served as director of the National Administration of Traditional Chinese Medicine sputum key research room, the State Administration of Traditional Chinese Medicine microcirculation three-level laboratory director, Beijing Institute of Chinese and Western Medicine combined with microvascular disease, and other positionsAt the international level, he is an executive member of the International Microcirculation Alliance, vice president of the Japan Society of Clinical Chinese Medicine, a member of the Japan Society of Microcirculation, deputy editor-in-chief of Microcirculation, and a deputy editor of Frontiers in Physiology-Vascular-Physiology; Declassifying the scientific connotation of the core theory of Chinese medicine is the original intention and mission Professor Han said that medical science research needs to face the country's major needsChronic non-infectious diseases are the main diseases that seriously threaten the health and medical finance of our people, and they are the key areas of clinical medicine prevention and treatment in ChinaThe fatality rate of these diseases accounts for 85% of the total disease death rate in Our country, consuming 75% of our country's total medical financeSince these diseases are complex diseases of network abnormality caused by a variety of factors, the drug interventions used to become the sole owner have not been completely solvedMicrovascular damage and microcirculation disorders and immune abnormalities are one of the main pathological bases of chronic non-infectious difficultyProfessor Han and his team focused on this field, long-term study of the heart, brain, lungs, liver, intestines and other organs of the mechanism of microvascular damage and microcirculation disorders, according to the theory of Chinese medicine blood and active hemorrhoids, to study the complex Chinese medicine and its main components to improve the role and mechanism of microcirculation disorders"In Chinese medicine, there is a systematic theory of hemorrhoids and activated hemorrhoids, " Explains Professor Han"The research goal of our team is to reveal the scientific connotation of the theory of hemorrhoids and activated blood clots in Chinese medicine theory, and to reveal the mechanism of the action of active hemorrhoid seismologyThe theory of hemorrhoids and live haemorrhoids is extended to the main battleground of the difficult-to-cure links of cardiovascular, diabetic microvascular comorbidities, shock and other diseases, and plays the role of Chinese medicine in blocking the progress of hemorrhagic-related diseases and reducing end-of-life medical expenses." In the cardiovascular field, microcirculation disorders are closely related to angina, myocardial infarction, heart failure, etcMicrovascular is a microvascular region consisting of small arteries, micro-arteries, capillaries, microves and small veins below 100 microns in diameter, and microcirculation is the circulation and exchange of gas and blood in the microvascular region Although the microvascular region accounts for 90% of the total number of blood vessels, but, because the naked eye is difficult to identify, so, clinical lack of diagnosis and treatment methods Professor Han Jingyan set up a machine dynamic visualization technology platform in the Medical Department of Peking University in 2004 to solve the problem of invisibility of the organs' microvascular and microcirculation In order to solve the problem of the intelling of the theory of hemorrhage and activated hemorrhage, Professor Han Jingyan used dynamic visualization techniques, combined with morphology, molecular biology, systembiology methods, under the guidance of Chinese medicine theory, carried out research work In cardiovascular disease, heart failure is an unresolved clinical problem In China, about 50% of patients with heart failure have coronary heart disease and 55% of patients have heart disease Professor Han Jingyan in 2004 put forward "can coronary heart disease intervention or thrombosis open vascular treatment, with regaslive blood compound Chinese medicine to solve the heart ischemia reperfusion injury, blocking myocardial fibrosis; In Chinese medicine, there is a theory of blood and gas fixation, but for thousands of years, its scientific connotation is not clear Based on more than a decade of research, Professor Han has put forward a scientific hypothesis: "The argon is made up of gas and rice, i.e oxygen (gas in heaven) and fine water and valley (ground gas)." Oxygen is inhaled by the lungs, the water valley is slightly ingested by the spleen and stomach, and the oxygen and the water valley are slightly composed of the ghetto The air outside the blood vessels is the gas, which provides the raw material for the production of ATP in the cells of the wired granules ATP assembles a single cytoskeleton G-actin into a rope-shaped F-actin (myokine), which assumes the role of gas line blood in the substructure of the heart muscle, which is a filament and coarse silk; The narrowness and latching of the coronary blood vessels, resulting in insufficient oxygen and water valley in the blood vessels, resulting in oxygen deficiency and lack of water in myocardial cells, ATP production is reduced, F-actin coagulation, the emergence of myocardial fiber stoic, low heart function, causing gas gas not to bleed; Modern medicine still lacks the theory and effective drugs of gas-replenishing blood and gas fixation, and there is also a lack of effective theory and medicine for heart failure characterized by low heart function (heart-breathing no blood) and fluid storage (gas-filled), so that the 5-year survival rate of patients with heart failure is less than 50% Using the ischemia re-injection model of rats, Professor Han's team confirmed that myocardial air void blood and pulse void ingemia were caused by abnormal oxidation stress and energy metabolism caused by abnormalmionofum respiratory chain, and revealed the mechanism of action mechanism of rehydration of the chinese medicine compound preparation of the chinese medicine preparation, ginseng gas droplets For this compound Chinese medicine, which has appeared many times in his academic papers and monographs, Professor Han gave a detailed description: "The ginseng gas droppills and their main regascomponents (e.g., jaundice, ginseng saponinRb1, Rg1, 37 saponinR1) improve the recovery of myocardial energy metabolism pathways, increase the expression and activity of mitochondrial complex V Restore the activity of ATP synthase, increase the production of endogenous ATP, promote the assembly of F-actin, restore the heart structure and heart function; "At the same time, Professor Han continued, "The ginseng gas dropper can also play a regulatory role on the endothelial blood vessels, inhibit the increase of the heart microvascular endothelial cytoplasm microscopic membrane caused by ischemic reperfusion, inhibit the low expression and re-emission of the blood vascular endothelial cell gap closely connected protein, reduce the oozing of plasma white protein, played a rehydration role." It is particularly important that, after the heart muscle damage caused by ischemia reperfusion, the xenon-beneficial gas droplets can also block myocardial fibrosis, which is achieved by suppressing the release of chemators, inhibiting the wandering and polarization of mononucleosis, inhibiting the release of TGF-beta 1, and inhibiting the activation of fibroblasts and collagen deposition "In addition, with the increase of pre-cardiac resistance caused by the rat heart muscle fertility model, Professor Han's team also confirmed that the ginseng gas droplets can reverse myocardial hypertrophy, blocking myocardial fibrosis, the effect of which is related to the regulation of cardiomyopathy energy metabolism pathways, inhibit oxidation stress, increase mitochondrial membrane transport protein, improve cardiomyocardial energy metabolism." It is worth mentioning that Professor Han Jingyan led the study of "the mechanism of the active blood action of ginseng-yi droplets to replenish the active blood" and also won the first prize of the Science and Technology Award of the Chinese Association of Chinese and Western Medicine in 2018  The development of chinese medicine depends on the progress of scientific research technology in our country, chronic non-infectious diseases, treatment with Western medicine alone, sometimes it is very difficult Professor Han pointed out that "a single-component-based Western medicine is not enough to solve the complexity of the problem, Traditional Chinese medicine caused by a variety of ingredients, it is possible to carry out multi-link regulation, and these experiences have been verified after thousands of years of clinical practice." He believes that "China's existing Chinese medicine, Western medicine, Chinese and Western combination of the multi-medical system is not in other countries' medical system, the special medical system." This kind of medical system has obvious advantages in maintaining the health of the people and solving the prevention and treatment of complex diseases To this end, China only used Europe, the United States, Japan, 7-15 elements of one of the medical finance to solve the health problems of 1.4 billion people However, the field of Chinese medicine is facing many opportunities and many challenges." In terms of opportunities, Chinese medicine theory and traditional Chinese medicine, in clinical use of more than 2,000 years, is the crystallization of the real world and big data The advantage of compound Chinese medicine is that it has many components, which can carry out complex regulation on many targets, solve the problem of network regulation and solve the problem of prevention and treatment of complex diseases However, due to the limitations of science and technology, it is not possible to fully and objectively display the scientific connotation of Chinese medicine Our understanding of Chinese medicine is far from sufficient In view of this, we need to solve the problem of how to solve the complexity network of multi-target regulation of the multi-component composition of compound Chinese medicine into blood or target organs, and to establish a research system to solve the complexity problem", in Professor Han's view, Chinese medicine has developed for more than 3,000 years, Western medicine has only 300 years of history, compared with 4 billion years of life, whether Chinese medicine, or Western medicine is too young, too small We need to combine the wisdom of Traditional Chinese medicine and Western medicine, with the help of scientific research capabilities and achievements of all mankind, using system biology, big data, dynamic visualization and other technologies and methods, using 5G, even 10G technology, to gradually reveal the scientific connotation of Chinese medicine theory and methods, to solve the problem of chronic non-induced diseases difficult to cure the prevention and treatment Professor Han, from his own perspective on the combination of Chinese and Western medicine, for example, microcirculation research Microcirculation is completely invisible to the naked eye and is less than 100 m in diameter, accounting for 90% of the microvascular system of the human blood vessel system gas blood patrol and exchange If you want to observe the flow rate of red blood cells in the microvascular, we need to use ultra-high-speed camera, to observe the vascular diameter changes of microvascular, endothelial cell damage, white blood cell adhesion, platelet adhesion, oozing, bleeding and other microcirculation disorders, we must be in a living state, with ultra-sensitive cameras connected to the biological microscope, microvascular amplification 200-400 times Professor Han said that at present, with the help of some instruments and equipment can be small animals of the brain, heart, lungs, liver, kidney, intestineand and other organs of the microvascular dynamic visualization and record, and then with the help of a variety of fluorescent probes, in the animal body to observe microcirculation changes However, because the human organs are not easy to be exposed, can only observe the human lips, tongue, the bottom of the eye and other microcirculation dynamics Plus, the various fluorescent marker probes on animals are not easy to use in the human body Thus, there has been a lack of relevant equipment and methods in the study of microcirculation disorders in the human body However, with the advance of optical technology, we have been able to observe the microcirculation of the human tongue, the future will be established tongue microcirculation map, to explore its application in diagnosis and efficacy determination To solve clinical problems and to build a production and a wide school in the future is the ideal state for Professor Han's desired combination of Chinese and Western medicine Discover the clinical problems, through multidisciplinary cross-cooperation, crack its implications of the scientific connotation of Chinese medicine theory at the same time, the research results need to be transformed into clinically available products, so that research becomes practical, therefore, there must be enterprise participation, without enterprise participation, it is difficult to achieve results Professor Han also admitted that scientific research should not stop at "scientific research", can not only "scientific research." We do not just do research for the sake of "research", it is not just scientific research Scientific research is not a stand-alone, it is the need for inter-disciplinary cooperation, the need for enterprises and scientific research units to support each other, scientific results to effectively solve the national and people's disease prevention, diagnosis and treatment problems The landing of scientific research results, in order to achieve our goal of learning, only meaningful For his team's future research planning blueprint, Professor Han is confident that, in the general direction, the future is still to face the difficult treatment of major diseases, such as oozing, bleeding, fibrosis, mucosa barrier, immune anomalies and tumor microenvironment and other issues, bringing together clinical, basic, pharmacological and other multidisciplinary teams, work together to crack the pathological basis of major diseases difficult to alleviate, reveal the effectiveness of Chinese medicine, clarify the scientific connotation of Chinese medicine From a small team, will continue to focus on the study of microcirculation disorders, from the gas false blood, gas hysteresis, hot blood, cold clotting blood, trauma blood clots and other five blood fields to crack its scientific connotation, reveal the mechanism of the action of activated blood-based antidote, for the Chinese medicine innovative drugs to provide candidates for the clinical use of Chinese medicine to provide scientific basis  
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