Professor Han Xiaojun's team of Harbin University of technology has made important achievements in the field of artificial organization

With the support of NSFC, Professor Han Xiaojun, a member of the State Key Laboratory of urban water resources and water environment, School of chemical engineering and chemistry, Harbin University of technology, made important progress in the field of artificial organization research The research achievement "programmed magnetic manipulation of vesicles into spatially coded protocol architectures arrays" was published in nature communications Professor Han Xiaojun is the only corresponding author, and Harbin University of technology is the only signing unit In nature, tissues are composed of cells arranged in a specific space, which perform higher-order biological functions than cells in an overall manner The research of tissue construction based on artificial cells can understand the evolution mechanism of multicellular organisms, and provide the basis for the design and construction of implantable artificial tissues In contrast to the attraction of ferromagnetic materials under magnetic field, antimagnetic materials such as cells are repulsed by magnetic field Generally, the magnetic susceptibility of antimagnetic materials is small, so the magnetic force can be ignored; according to the magnetic Archimedes effect, the introduction of paramagnetic media can enhance the role of antimagnetic materials, and drive the antimagnetic materials to move to the region with the weakest local magnetic field Using the above principle, the artificial cells are assembled into various tissue forms with special spatial arrangement in the stainless steel mesh The constructed artificial tissue showed abnormal stability under the condition of high salt concentration (1m) and pure water, which reflected the population-specific behavior of this kind of structure, indicating that in the process of life evolution, cell population had survival advantage over single cell At the same time, the cascade reaction of artificial cells and the chemical exchange between artificial cells and cell colonies were studied The artificial tissue construction method presented in this paper has a wide application prospect in synthetic biology and tissue engineering (source: nature Communications) Professor Han Xiaojun has been engaged in research in the field of artificial cells for many years, and has made a series of high-level research results in recent years In the Journal of the American Chemical Society (j.am Chem SOC., 2017, 139, 9955, impact factor 14.357), advanced materials (adv mater., 2018, 30, 1707482, impact factor 21.950) ）, ACS Nano (2014, 8, 3961; 2019, 3, 3573, impact factor 13.709), cell sub Journal iscience (2018, 8, 138), chemical science, 2019, 10, 9446, impact factor 9.556) and other journals published a series of research papers, some of which are hot spots, VIP, cover papers; presided over more than 20 projects such as the National Natural Science Foundation, the New Century Excellent Talents fund of the Ministry of education, Heilongjiang outstanding youth fund, etc., and so far published more than 150 SCI papers.