Professor Li Jing: Why is methotrexate so classic & how is methotrexate safe to use?

Methotrexate, a classic antirheumatic drug in rheumatology, is also the gold standard for rheumatoid arthritis treatment resear.

Methotrexate, a classic antirheumatic drug in rheumatology, is also the gold standard for rheumatoid arthritis treatment resear.

Mays Medical specially invited Professor Li Jing from Peking Union Medical College Hospital

Why can methotrexate stand out from the crowd of anti-rheumatic drugs and become the most classic anti-rheumatic drug?

Why can methotrexate stand out from the crowd of anti-rheumatic drugs and become the most classic anti-rheumatic drug? Why can methotrexate stand out from the crowd of anti-rheumatic drugs and become the most classic anti-rheumatic drug? Why can methotrexate stand out from the crowd of anti-rheumatic drugs and become the most classic anti-rheumatic drug?

There are two main reasons why methotrexate has become a classic antirheumatic dr.

There are two main reasons why methotrexate has become a classic antirheumatic dr.

One aspect is the effectiveness of methotrexate in the treatment of conditions such as rheumatoid arthrit.

 

On the other hand , methotrexate is widely used in rheumatologic disease.

On the other hand, the application of methotrexate in rheumatological diseases is also very extensiv.

When choosing methotrexate for a patient, what tests should be done and what problems should be ruled out?

When choosing methotrexate for a patient, what tests should be done and what problems should be ruled out? When choosing methotrexate for a patient, what tests should be done and what problems should be ruled out?

 

 

Risk factors for serious adverse reactions should be evaluated before methotrexate u.

What are the advantages of subcutaneous methotrexate? Why is it not widely used?

What are the advantages of subcutaneous methotrexate? Why is it not widely used? What are the advantages of subcutaneous methotrexate? Why is it not widely used? What are the advantages of subcutaneous methotrexate? Why is it not widely used?

Although the guidelines clearly indicate that oral methotrexate is a better choice for the treatment of rheumatoid arthritis , gastrointestinal discomfort caused by oral methotrexate is still a common adverse reaction in many patients, and this adverse The occurrence of the reaction was dose-related with methotrexa.

Although the guidelines clearly indicate that oral methotrexate is a better choice for the treatment of rheumatoid arthritis , gastrointestinal discomfort caused by oral methotrexate is still a common adverse reaction in many patients, and this adverse The occurrence of the reaction was dose-related with methotrexa.

Methotrexate is an anti-tumor drug origin and has certain cytotoxici.

Methotrexate is an anti-tumor drug origin and has certain cytotoxici.

Methotrexate is a folic acid antagonist, which mainly inhibits dihydrofolate reductase, so that dihydrofolate cannot be reduced to tetrahydrofolate with physiological activity, so as to make the raw materials of purine nucleotides and pyrimidine nucleotides required for DNA synthes.

Folic acid-reducing structure leucovorin is converted into tetrahydrofolate under the action of tetrahydrofolate reductase, which can be used for the rescue of severe toxicity when a large amount of methotrexate is used or a large amount of methotrexate is taken by mista.

Folic acid-reducing structure leucovorin is converted into tetrahydrofolate under the action of tetrahydrofolate reductase, which can be used for the rescue of severe toxicity when a large amount of methotrexate is used or a large amount of methotrexate is taken by mista.

When bone marrow suppression occurs, first stop methotrexate, review the blood routine, and judge whether it is necessary to use leukocyte-raising drugs according to the blood routi.

When liver function damage occurs, if the liver function is not significantly increased, the drug can be continued, but the liver function needs to be monitored regular.

If the liver function is significantly increased by more than two times, it is necessary to stop methotrexate and give liver protection therapy , to avoid more serious liver dama.

The incidence of pulmonary fibrosis is low, and the patient's previous pulmonary fibrosis is not a contraindication to methotrexa.

However, if it is more obvious pulmonary fibrosis, methotrexate should be avoid.

If acute interstitial pneumonia occurs during treatment, methotrexate should be discontinued first, and the cause should be identified while active treatme.

The incidence of renal impairment is also low, but it is recommended to avoid methotrexate if possib.

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