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    Home > Active Ingredient News > Digestive System Information > Professor Li Juxiu of Xinong and Researcher An Wei of Ningxia Agriculture and Forestry Institute MNFR: AC improves intestinal barrier damage and inflammation induced by high-fat diet

    Professor Li Juxiu of Xinong and Researcher An Wei of Ningxia Agriculture and Forestry Institute MNFR: AC improves intestinal barrier damage and inflammation induced by high-fat diet

    • Last Update: 2021-04-27
    • Source: Internet
    • Author: User
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    Innovation: The team of Professor Li Juxiu of Xinong and the team of researcher An Wei of Ningxia Academy of Agriculture and Forestry found that Lycium ruthenicum anthocyanins can enrich intestinal short-chain fatty acid producing bacteria (Rumenococcus, Bacteroides, etc.
    ), increase the content of SCHAs, and reduce production.
    Endotoxin bacteria (such as Helicobacter and Desulfovibrioceae) and reduce the level of endotoxin (such as LPS); it can activate GPRs, inhibit HADC activity, reduce intestinal permeability, protect the integrity of intestinal barrier, and improve intestinal inflammation reaction.

    Keywords: Lycium ruthenicum anthocyanins, high-fat diet, intestinal flora, colonic barrier dysfunction, inflammation of the colon, Lycium ruthenicum Murr.
    (Lycium ruthenicum Murr.
    ), as a unique medicinal and edible plant resource in Northwest China, its fruit It has a variety of physiological functions such as lowering lipid, lowering blood sugar, anti-oxidation and anti-obesity, and is safe and non-toxic.
    It is an ideal edible product.

    Known as the "king of anthocyanins", Lycium ruthenicum anthocyanins (AC) are rich in fruit, among which petunia anthocyanins are as high as 97% and aromatic acids are acylated.

    In 2018, Professor Li Juxiu's team and An Wei researcher team (Baoming Tian; Jianhua Zhao; Wei An; Jiawei Zhang; Xin Cao; Jiale Mi; Jinsong Zhao; Yingxiao Zhang; Juxiu Li(*), Lycium ruthenicum diet alters the gut microbiota and partially enhances gut barrier function in male C57BL/6 mice, Journal of Functional Foods, 2019, 52: 516-528) reported that Lycium ruthenicum can change the intestinal flora of normal mice, promote the production of intestinal SCFAs, and reduce LPS content , Enhance the intestinal barrier function.

    Elimination of intestinal flora with antibiotics confirms that the effect of dietary supplementation of Lycium ruthenicum on intestinal health is related to the improvement of intestinal flora and intestinal mucosal barrier function.
    It is necessary to explore the material basis and mechanism of the effects of Lycium ruthenicum.

    The research team used Lycium ruthenicum as the raw material to extract and purify Lycium ruthenicum anthocyanins (AC).
    Using mice induced by a high-fat diet as an animal model, the research team studied the effects of Lycium ruthenicum anthocyanins on the body weight and intestinal flora of mice.
    Intervention effects of intestinal metabolites, intestinal barrier, and intestinal inflammation: Studies have found that AC can regulate the imbalance of intestinal flora and reduce the colon barrier damage and intestinal inflammation in mice induced by high fat.

    The relevant results were published in Molecular Nutrition & Food Research.

    AC can reduce the weight gain of mice induced by HFD, and increase the OTU and α diversity of the mouse flora induced by HFD, change the β diversity of the flora closer to the control mice, and reduce Firmicutes and Bacteroides At the same time, AC increased the relative abundance of SCFAs-producing bacteria such as Rumen Bacteria, Muribaculaceae, Akkermansia, Ruminococcaceae_UCG-014 and Bacteroides, and decreased the abundance of LPS-producing bacteria such as Desulfovibrioceae and Helicobacter.

    AC can increase the content of SCFAs in the colon contents and stool samples of mice induced by HFD, and reduce the pH, free ammonia and LPS content of the intestine and stool.

    AC ameliorated pathological damages such as inflammatory cell infiltration and edema in intestinal tissue caused by HFD, increased the length of HFD-induced mouse colon microvilli, by activating G GPRs and inhibiting HDACs activity, increasing tight junction mRNA and protein expression levels, and improving The tight junction structure of the colon reduces the permeability of the intestine and enhances the barrier function of the intestine; AC reduces the intestinal inflammation in mice caused by HFD by inhibiting the LPS/TLR4/NF-κB signaling pathway.

    The above-mentioned research work was supported by the special fund for basic scientific research operations of central universities (2452019181); the National Natural Science Foundation (31360191); the Ningxia Hui Autonomous Region Science and Technology Innovation Leading Talent Project (KJT2017004); and the Ningxia Hui Autonomous Region Agricultural Breeding Special Fund (2013NYYZ0101) .

    Acknowledgements: The completion of this work is particularly grateful for the support of researcher An Wei and associate researcher Zhao Jianhua of Ningxia Academy of Agriculture and Forestry Sciences.
    The Wolfberry Science Institute of Ningxia Academy of Agriculture and Forestry Sciences was established in 2005 and is a scientific research institution engaged in the professional research of wolfberry.

    Focusing on the five research directions of wolfberry germplasm resource evaluation, new variety breeding, cultivation and mechanical equipment development, genomics and wolfberry storage and product deep processing, scientific research and achievement transformation application will be carried out, and a wolfberry germplasm resource storage library and laboratory will be built , Pilot production workshop and other research platforms, completed 49 achievement registrations, and obtained 1 major scientific and technological contribution award of the autonomous region, 1 first prize, 2 second prizes, 5 third prizes, and 1 Liangxi prize.

    Selected 8 new varieties of wolfberry, developed 9 deep-processed products of wolfberry, obtained 11 invention patents, formulated 35 local standards, published 112 papers, including 17 SCI papers and 4 monographs.

    WILEY paper information: Lycium ruthenicum anthocyanins attenuate high-fat diet-induced colonic barrier dysfunction and inflammation in mice by modulating the gut microbiotaBaoming Tian; Jianhua Zhao; Min Zhang; Zhifei Chen; Qingyu Ma; Huicui Liu; Chenxi Nie; Ziqi Zhang; Wei An(*), Juxiu Li(*), Molecular Nutrition & Food Research DOI: 10.
    202000745 Click "Read the original text" in the lower left corner to view the original text of the paper.

    Molecular Nutrition & Food Research Journal Introduction Wiley's Molecular Nutrition & Food Research journal was founded in 1957, focusing on publishing cutting-edge research work on health, safety and all related molecular nutrition fields.

    The manuscript covers topics including nutritional biology, nutrigenomics, metabolomics, etc.

    The 2020 impact factor is 5.

    Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
    Follow us to share cutting-edge information|Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
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