Professor Lu Weiyue's research group and collaborators of Fudan University have developed a novel biomimetic nanodrug for the efficient treatment of glioma

The research team of Professor Lu Weiyue of Fudan University School of pharmacy and Professor Zhang LiangFang of University of California, San Diego (UCSD) developed an active target bionic nanodrug with drug nanocrystals covered by red cell membrane, and carried out relevant research on anti glioma treatment Recently, this achievement was published online in ACS Nano (DOI: 10.1021 / acsno 9b00661) under the title of "live modified cell membrane enables the targeted delivery of drug nanocrystals to glioma" At present, the clinical treatment of gliomas is mainly surgical resection, supplemented by radiotherapy and chemotherapy Because of the lack of obvious boundary of brain glioma, it is difficult to remove it completely and easily lead to recurrence; at the same time, the existence of multiple barriers at the brain glioma site hinders the access of chemotherapy drugs, resulting in the failure of obtaining effective drug concentration at the tumor site; the use of high-dose chemotherapy drugs will also bring a variety of serious side effects How to improve the concentration of anti-tumor drugs in the brain gliomas and reduce systemic side effects while improving the efficacy? The research team of Professor Lu Weiyue, School of pharmacy, Fudan University, has constructed an active target bionic nanodrug, using 1) the strategy of coating drug nanocrystals with red cell membrane One is to extend the circulation time of the drug in the blood by using the red blood cell membrane, so as to create more chances for the drug to enter the focus; the other is to increase the drug loading to increase the concentration of the bionic nano drug in the focus every time; the second is the strategy of target molecule mediated crossing the barrier membrane The target molecule which can recognize the brain glioma barrier membrane is inserted into the red cell membrane, and the biomimetic nano drug is endowed with the drug accumulation in the focus and tumor cells, so as to play a better drug treatment effect In this study, the red cell membrane was coated outside the drug nanocrystalline "Biomimetic protective layer" enables the prepared biomimetic nanodrug to have the advantages of natural red blood cell membrane and drug nanocrystals at the same time, i.e large drug loading, high stability, good biocompatibility and long blood circulation time; the surface of red blood cell membrane is modified with target molecule C (rgdyk), so that the prepared biomimetic nanodrug has the ability of target recognition for tumor neovascularization and tumor cells at the same time The drug crossed the blood-brain tumor barrier and delivered to the tumor cells, effectively and accurately attacked glioma, and ensured the safety of treatment under the condition of high-dose chemotherapy The preparation process of the active target bionic nanodrug is simple, environmental friendly and easy to industrialize At the same time, the research results also provide a new choice for the clinical treatment of brain tumors and peripheral solid tumors, with a good application prospect Chai Zhilan, Ph.D student, School of pharmacy, Fudan University, is the first author of the paper, and Professor Lu Weiyue and Professor Zhang LiangFang, University of California, San Diego, are the co correspondents of the paper The research was supported by national major scientific research program, NSFC, scientific research and innovation program of Shanghai Education Commission and international science and technology cooperation program of Shanghai Science and Technology Commission.