Professor Qian Feng's research group from Shanghai Jiaotong University discovered a new mechanism of asthma regulation

Asthma is a common chronic respiratory disease with more than 300 million patients worldwide and a serious threat to human health

On March 25, 2022, Professor Qian Feng's research group from the School of Pharmacy, Shanghai Jiao Tong University published a long article titled AMFR drives allergic asthma development by promoting alveolar macrophage in the Journal of Experimental Medicine (IF=14.

Research Introduction

The autocrine motility factor receptor (AMFR), also known as gp78, is an endoplasmic reticulum-resident E3 ubiquitin ligase that recognizes misfolded proteins, ubiquitinates them, and ubiquitinates them.

In this study, the researchers analyzed the differential genes in AMs of asthma model mice by whole-genome sequencing, and found for the first time that the expression of Amfr gene was specifically up-regulated in AMs

Summarize

Alarmin TSLP is a novel drug target for the treatment of asthma.

Professor Qian Feng and Associate Researcher Sun Lei from the School of Pharmacy, Shanghai Jiao Tong University are the co-corresponding authors of the paper, and Zhang Huihui, a doctoral student from the School of Pharmacy, Shanghai Jiao Tong University, is the first author of the paper

Link to the paper : https://rupress.