Professor Qiu Xiaobo, Ofsashi Shida, has many surprises in the field of protein modification and degradation.

Introduction: Protein is the main implementer of life activities, and its modification and degradation are associated with all life activities, and it is an eternal theme in the field of life medicine. Professor Qiu Xiaobo,
, is an outstanding scholar in the field of "protein modification and degradation", has won the National Distinguished Youth Fund, the National Ministry of Personnel high-level study abroad talent fund, and was shortlisted for the "100 million talent project" national candidate. "Protein sisaves are the main implementers of life activities, and their modification and degradation are associated with all life activities and are an eternal theme in the field of life medicine,"
stressed in an interview with Biodiscovery.
", Professor Qiu Xiaobo 1, change direction: from pharmacy to cell biology in 1996, just graduated from the University of Southern California School of Pharmacy, Qiu Xiaobo did not follow the common sense of the "drug research" this way.
" the idea was simple: it was that the development of drugs required understanding of how diseases occur.
I applied to join Harvard Medical School and began my research in cell biology.
," Professor Qiu Xiaobo recalled.
postdoctoral phase, his team focused on the study of ubiquitin-protease, a major pathway for protein degradation in cells.
, ubiquitin is a way of modifying proteins and a popular topic in the field of epigenetics, while the main function of proteases is to clean up labeled proteins, which has become a drug target of much attention in the field of disease treatment.
nearly 20 years of research, Professor Qiu Xiaobo has made several original breakthroughs - discovering the new ubiquitin-linked enzyme Nrdp1, and confirming that the degradation of the nrdp1-mediated apoptosis inhibitor LEUS is a new way to trigger apoptosis; Asked about the secret,
, he smiled and said, "It's a wide field, full of unknowns and surprises."
"2," the unique path: mining the secret of protein modification, degradation in 2013, has been in Beijing Normal University for more than 4 years, Professor Qiu Xiaobo led the team to reveal the mechanism of histone degradation, and this discovery also subverted the scientific community on the "somatic histone synonythane non-degradation" view.
they confirmed that acetylide mediated core histones were degraded by specific proteases during the repair of somatic cell DNA damage and sperm production.
this groundbreaking study, published in the authoritative academic journal Cell, is expected to open up new research directions for "acetylation mediated protein degradation".
subsequently, based on years of accumulation of ubiquitin studies, his team was involved in finding the mechanism of TB invasion, confirming that the bacteria uses host ubiquitin to activate its inhibition of the host's inherent immune response.
results provide new clues to tuberculosis treatment. Professor Qiu Xiaobo,
, said the team's next step would be to focus on the ubiquitin-protease.
based on the critical role of unonophine-protease pathways in disease development, he hopes to continue the "original intent" of the PhD phase and continue drug development for targets found in basic research.
3, about scientific research: subject selection and focus are equally important In 2008, Professor Qiu Xiaobo joined the School of Life Sciences of Beijing Normal University, forming a research team, while also taking on teaching tasks, including undergraduates' "Molecular Biology" bilingual courses and several graduate courses.
on his career, he said, "The main task of the university is to 'teach and educate people', and at the same time to be able to carry out their own interest in scientific research, which makes me very content and enjoy."
" Professor Qiu Xiaobo also admitted that scientific research is not a simple career choice.
for young scholars, of course, need to consider the "survival plan", but the most important thing is to find the right research direction and insist on their choice.
for the conference to promote the role of academic, Professor Qiu Xiaobo gave full recognition: "At present, the country attaches importance to scientific innovation."
with the help of such a large-scale academic platform as the Cold Spring Hong Kong Conference, domestic scholars can communicate equally with foreign big curry and learn from each other.
so we're in a great time.
"