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    Home > Professor Ren Lei, Xiamen University Research Group: virus like particles -- a new safe nano anti-tumor drug carrier

    Professor Ren Lei, Xiamen University Research Group: virus like particles -- a new safe nano anti-tumor drug carrier

    • Last Update: 2018-06-11
    • Source: Internet
    • Author: User
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    With the rapid development of tumor diagnosis and treatment, nano materials as the carrier and multi-mode medical image-based integrated approach to tumor diagnosis and treatment is expected in solid tumor treatment, because it can not only detect tumor with high sensitivity and specificity, but also provide a better scheme for tumor treatment Virus like nanoparticles (VLPs) are protein nanostructures without viral nucleic acids It is similar to natural virus particles in morphology and structure, with strong biological activity and high safety Some VLPs have been successfully used as vaccines Recently, Professor Ren Lei, School of materials, Xiamen University, cooperated with Professor Nie liming, School of public health, and researcher Bi Shengli, China Center for Disease Control and prevention to prepare rgd-hbc / ICG VLPs (DOI: 10.1002/adma.201707567), a new nano antitumor drug carrier with high cell uptake efficiency and good biocompatibility Prof Ren Lei, Dr Ren Lei, Professor of the Department of biomaterials, School of materials, Xiamen University In 1990, he received a bachelor's degree in engineering from Tianjin University, a master's degree in science from China Union Medical University in 1997, and a doctor's degree in philosophy from Okayama University in Japan in 2001 From 1990 to 1997, he worked as an intern researcher in the Institute of Biomedical Engineering, Chinese Academy of Medical Sciences; from 2001 to 2003, he worked as a SMA postdoctoral researcher in the National University of Singapore; since 2012, he has successively served as an associate professor and professor of Xiamen University He has been engaged in the research of biomaterials and nanodrugs / gene carriers for a long time At present, the main research directions include: (1) to construct multifunctional response (pH, light, heat and other stimulation induction) composite materials, and to explore the targeting and transmembrane transport efficiency of multi-component nanostructure complexes to tumor cells / tissues with the help of different targeted biomolecules (2) In order to realize the recognition and diagnosis of tumor cells, the relationship between the changes of biological microenvironment and the conformation of specific molecules in the nanocomposite was discussed, and the regularity between the changes of cell microenvironment and the changes of signal intensity in the nanocomposite was established (3) To develop new composite scaffolds for tissue engineering and to explore the material cell interface In the past decade, he has undertaken and participated in more than 20 scientific research projects related to nano biomaterials, including the joint fund of NSFC for promoting cross strait scientific and technological cooperation (one for hosting), national general fund for Natural Science (five for hosting), 973 Program (three for participating), etc As of May 2018, he has published more than 90 research papers included in SCI in academic journals, which have been cited for more than 1000 times; he has been granted 10 Chinese invention patents; he has won the second prize of 2012 Xiamen science progress (ranking second) and 2012 Japan Science and technology exchange Award of Japan China Science Association; he has been invited to participate in the preparation of Transworld Nanostructured materials for biomedical applications (ISBN: 978-81-7895-397-7), published by Research Network Press Leading edge scientific research achievements: virus like particles, a new and safe nano anti-tumor drug carrier, in the early research, Professor Ren Lei, Professor Zhang Xianzhong of Public Health College of Xiamen University and researcher Bi Shengli of China CDC cooperated to assemble multiple modular functional peptides into VLPs by using genetic engineering technology The carrier can not only effectively load adriamycin, but also target tumor cells specifically The results of animal experiments show that the nano drug delivery system can inhibit the growth of tumor cells up to 100 times, and has little side effects The relevant research results were published online on nanomedicine: nanotechnology, biology and medicine (DOI: 10.1016 / j.nano 2017.12.002) under the title of "modified peptides modified HBC virus like particles for encapsulation and tumor targeted delivery of dioxorubicin" Schematic diagram: self assembly process and animal experiments (source: nanomedicine: nanotechnology, biology and medicine) recently, Professor Ren Lei, in cooperation with Professor Nie Liming and researcher Bi Shengli, inserted tumor targeting peptide RGD into the main immunogenic ring area exposed on the surface of HBC protein through gene engineering technology, thus preparing RGD HBC VLPs The virus like particles used in this study can not only enter tumor tissue specifically, but also be completely degraded into amino acids after release of drugs in the acidic environment of tumor cells, achieving the therapeutic effect of specific anti-cancer and non-toxic side effects Indocyanine green (ICG) is a kind of near-infrared dye It is also one of the few dyes approved by FDA for clinical application Because ICG has poor stability in aqueous solution and is easy to decompose in light, its further clinical application is limited By regulating the self-assembly process of VLPs, RGD HBC / ICG VLPs can be prepared by loading fluorescent dye ICG into a positive cavity, so as to improve the stability of ICG, prolong its circulation time in vivo, improve the efficiency of cell uptake, and effectively deliver it to the tumor site The results show that rgd-hbc / ICG VLPs has high cell uptake efficiency and good biocompatibility, and can realize dual-mode imaging of fluorescence and photoacoustic in mice, so it is hopeful to detect tumor with high sensitivity and specificity Under the irradiation of 808 nm near infrared laser, rgd-hbc / icgvlps can also produce photothermal / photodynamic effects, and significantly ablate the tumor tissue loaded by mice Schematic diagram: the preparation process of rgd-hbc / icgvlps and the related research results of photothermal / photodynamic therapy principles (source: Advanced Materials) were published online on advanced materials with the title of "improved stable indocyanine green (ICG) - mediated cancer optotheranostics with naturally occurring therapies B core particles" (DOI: 10.1002 / ADMA 201707567) The first co authors of this paper are Shan Wenjun, Ph.D student, School of materials, Xiamen University and Chen Ronghe, Ph.D student, School of public health Professor Ren Lei and Professor Nie Liming are co correspondents This work has been supported by NSFC's joint fund for promoting cross strait scientific and technological cooperation and other projects Nowadays, people and scientific research have been paid more and more attention in the economic life China has ushered in the "node of science and technology explosion" Behind the progress of science and technology is the work of countless scientists In the field of chemistry, in the context of the pursuit of innovation driven, international cooperation has been strengthened, the influence of Returned Scholars in the field of R & D has become increasingly prominent, and many excellent research groups have emerged in China For this reason, CBG information adopts the 1 + X reporting mechanism CBG information, chembeango app, chembeango official microblog, CBG wechat subscription number and other platforms jointly launch the column of "people and scientific research", approach the domestic representative research group, pay attention to their research, listen to their stories, record their demeanor, and explore their scientific research spirit.
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