Professor Xia Ningshao of Xiamen University and Professor Guan Yi of the University of Hong Kong jointly published an article: the pathogenic mechanism of the new coronavirus and gender factors

A few days ago, Professor Xia Ningshao’s team and Professor Guan Yi’s team from the University of Hong Kong published an online new study titled "Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster" in the Journal of Signal Transduction and Targeted Therapy.

The outbreak of the new crown virus poses a serious threat to global public health, and has caused more than 150 million infections and 3 million deaths to date

The team of Professor Xia Ningshao and the team of Professor Guan Yi of the University of Hong Kong jointly carried out model construction and comparative research based on Syrian golden hamsters susceptible to the new coronavirus

Pulmonary pathology test results showed that the lungs of male hamsters after infection may have large areas of alveolar parenchymal lesions, inflammatory immune cell recruitment and infiltration, diffuse hemorrhage, mucus stasis embolism, abnormal accumulation of collagen fibers and other serious pathology The changes are similar to the clinical symptoms of new coronary pneumonia such as interstitial pneumonia, alveolitis, severe pneumonia, pulmonary edema, and pulmonary fibrosis; the degree of lung tissue lesions, lesion area and complexity of female hamsters after infection are generally weaker than Male gophers

Studies have also found that under different challenge doses, male hamsters can have more extensive lung infections and more severe tissue damage at low doses, while only mild tissue damage is observed in the lungs of female hamsters

Postdoctoral fellows Yuan Lunzhi, doctoral student Ma Jian, master's student Zhou Ming, Professor Zhu Huachen and Engineer Chen Rirong from the University of Hong Kong are the co-first authors, and Professor Xia Ningshao, Professor Cheng Tong and Professor Guan Yi from the University of Hong Kong are the co-corresponding authors

Link to the paper: https:// .